Robustaflavone 4′-methyl ether
Robustaflavone 4′-methyl ether is a biflavonoid compound that can be isolated from the whole plant of Selaginella gracillima. Robustaflavone 4′-methyl ether inhibits the growth of cancer cells. Robustaflavone 4′-methyl ether can be used in the research of EBV-transformed B-cell carcinoma and lung cancer.
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- CAS No.: 275365-36-1
- 화학식: C31H20O10
- 분자량:552.48
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
25.64 μM
Compound: 6
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Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 29921475] |
Robustaflavone 4′-methyl ether (Compound 1) (12.5-100 μM; 3 days) significantly inhibits the growth of Raji and Calu-1 cell lines in a concentration-dependent manner, but exhibits only extremely weak or even no inhibitory activity against K562, HeLa, Vero and Wish cell lines; at the concentration of 100 μM, its maximum inhibition rate reaches 98.4 % for Raji cells and 100 % for Calu-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Raji, Calu-1, K562, HeLa, Vero, Wish cell lines
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Concentration:12.5, 25, 50, 100 μM
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Incubation Time:3 days
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Result:Inhibited Raji cell growth by 98.4% and Calu-1 cell growth by 100% at 100 μM.
Inhibited Raji cell growth by 68.5% and Calu-1 cell growth by 77.9% at 50 μM.
Inhibited Raji cell growth by 60.7% and Calu-1 cell growth by 44.6% at 25 μM.
Inhibited Raji cell growth by 34.2% and Calu-1 cell growth by 42.6% at 12.5 μM.
Chemical Information
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CAS No. 275365-36-1
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분자량 552.48
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화학식 C31H20O10
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SMILES
O=C1C=C(C2=CC(C3=C(C=C4OC(C5=CC=C(O)C=C5)=CC(C4=C3O)=O)O)=C(OC)C=C2)OC6=C1C(O)=CC(O)=C6
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Robustaflavone 4′-methyl ether Related Classifications
HY-N18310 Related Classifications
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