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Cat. No.: HY-184954

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SIK-IN-6

SIK-IN-6 is a selective SIK3 inhibitor with an IC₅₀ of 15 nM. SIK-IN-6 exerts anticancer activity in acute myeloid leukemia with high MEF2C expression, but does not exhibit significant anticancer activity in acute myeloid leukemia with low MEF2C expression or in ovarian cancer. SIK-IN-6 can be used for the research of acute myeloid leukemia.

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화학식: C₂₆H₂₄F₂N₄O₃
분자량:478.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SIK-IN-6 Chemical Structure

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

SIK3

15 nM (IC₅₀)

SIK1

130 nM (IC₅₀)

SIK2

200 nM (IC₅₀)

All Salt-inducible Kinase (SIK) Isoforms :

In Vitro

SIK-IN-6 (Compound 39) potently inhibits purified SIK3 with an IC₅₀ of 15 nM, and shows weaker inhibition of purified SIK1 (IC₅₀ 130 nM) and SIK2 (IC₅₀ 200 nM), along with favorable in vitro ADME properties^[1].
SIK-IN-6 (0.001-100 μM; 4 days) induces cytotoxicity in MEF2C-high MOLM13 AML cells with a GI₅₀ of 1500 nM^[1].
SIK-IN-6 (0.001-100 μM; 3 days) selectively induces cytotoxicity in MEF2C-high MV4-11 AML cells with a GI₅₀ of 1200 nM, while sparing MEF2C-low U-937 AML cells and noncancerous HEK-293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MOLM13 (MEF2C-high AML) cells
Concentration:

0.001-100 μM
Incubation Time:

4 days
Result:

Induced cytotoxicity with a GI₅₀ of 1500 nM.

Cell Viability Assay^[1]

Cell Line:

MV4-11 (MEF2C-high AML), U-937 (MEF2C-low AML), and HEK-293 (noncancerous) cells
Concentration:

0.001-100 μM
Incubation Time:

3 days
Result:

Induced cytotoxicity in MV4-11 cells with a GI₅₀ of 1200 nM.
Showed no significant cytotoxicity in U-937 cells (GI₅₀ 29000 nM).
Showed no significant cytotoxicity in HEK-293 cells (GI₅₀ >30000 nM).

Chemical Information

분자량 478.49
화학식 C₂₆H₂₄F₂N₄O₃
SMILES

COC1=CC(C2=CN=C3N2C=CC(C4=CC(C)=NC(C)=C4)=C3)=CC(OC)=C1C(N5CC(F)(C5)F)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Webb DT, et al. Structure–activity relationship studies resulting in the identification of potent and selective salt-inducible kinase inhibitors. ACS Med Chem Lett. 2016;7(7):726-731.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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SIK-IN-6

All Salt-inducible Kinase (SIK) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SIK-IN-6 Related Classifications

HY-184954 Related Classifications