STING agonist-12
Based on 2 publication(s) in Google Scholar
STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.35%
- CAS No.: 2259624-71-8
- 화학식: C25H19ClF4N2O2
- 분자량:490.88
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) STING agonist-12
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Customer Validation & Images
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Biological Activity
EC50: 185 nM (STING)[1]
STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells[1].
STING agonist-12 is not active at mouse STING[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice (n=3)[1]
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Dosage:5 or 10 mpk
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Administration:Lateral tail vein or oral gavage (Pharmacokinetic Analysis)
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Result:Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse[1].
Route DOSE
(mpk)AUC
(ng/mL*h)T1/2
(h)Cmax
(ng/mL)Vd
(mL/kg)F
(%)IV 5 1215 1.41 1867 2689 NA PO 10 2090 NA 1723 NA 86
Chemical Information
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CAS No. 2259624-71-8
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Appearance Solid
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분자량 490.88
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화학식 C25H19ClF4N2O2
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Color Light yellow to yellow
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SMILES
ClC1=CC=CC(F)=C1CN2C3=C(C(C)(C2=O)C)C=CC(C(NCC4=C(C=C(C=C4F)F)F)=O)=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Immunity
A chemical agonist and the Golgi-resident lipid PI4P activate STING by inducing transmembrane helix rearrangement. [Abstract]2025 Dec 5:S1074-7613(25)00506-0. PMID: 41352342
STING agonist-12 purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Dec 5:S1074-7613(25)00506-0. [Abstract]
THP1-Lucia ISG cells were treated with GNE-6468 (25 μM), STING agonist-12 (C53, 10 μM), and NVS-STG2 (5 μM) in the presence or absence of BFA (1 μM) for 6 h. Activation of the STING pathway was analyzed by immunoblotting.
STING agonist-12 purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Dec 5:S1074-7613(25)00506-0. [Abstract]
Western blot analysis of the LC3 conversion in WT HEK293T cells and HEK293T cells stably expressing hSTING stimulated with cGAMP (4 μM), GNE-6468 (25 μM), and STING agonist-12 (C53, 10 μM) for 8 h.
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J Med Chem
Design, Synthesis, and Biological Evaluation of Selective STING Synergists That Enhance cGAMP-STING Pathway Activation without Inherent Agonist Activity. [Abstract]2025 Apr 29. PMID: 40298091
용액&용해도
DMSO : 250 mg/mL (509.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0372 mL | 10.1858 mL | 20.3716 mL | 50.9289 mL |
| 5 mM | 0.4074 mL | 2.0372 mL | 4.0743 mL | 10.1858 mL | |
| 10 mM | 0.2037 mL | 1.0186 mL | 2.0372 mL | 5.0929 mL | |
| 15 mM | 0.1358 mL | 0.6791 mL | 1.3581 mL | 3.3953 mL | |
| 20 mM | 0.1019 mL | 0.5093 mL | 1.0186 mL | 2.5464 mL | |
| 25 mM | 0.0815 mL | 0.4074 mL | 0.8149 mL | 2.0372 mL | |
| 30 mM | 0.0679 mL | 0.3395 mL | 0.6791 mL | 1.6976 mL | |
| 40 mM | 0.0509 mL | 0.2546 mL | 0.5093 mL | 1.2732 mL | |
| 50 mM | 0.0407 mL | 0.2037 mL | 0.4074 mL | 1.0186 mL | |
| 60 mM | 0.0340 mL | 0.1698 mL | 0.3395 mL | 0.8488 mL | |
| 80 mM | 0.0255 mL | 0.1273 mL | 0.2546 mL | 0.6366 mL | |
| 100 mM | 0.0204 mL | 0.1019 mL | 0.2037 mL | 0.5093 mL |
STING agonist-12 Related Classifications
HY-147010 Related Classifications
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