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Cat. No.: HY-153546

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STING agonist-31

STING agonist-31 is a STING agonist, with EC₅₀ values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency.

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CAS No.: 2719001-44-0
화학식: C₄₃H₅₁N₁₅O₆
분자량:873.96

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

STING agonist-31 Chemical Structure

CAS No.: 2719001-44-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

STING agonist-31 is a STING agonist, with EC₅₀ values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency^[1].

In Vitro

STING agonist-31 (Compound 40) activates h-STING and m-STING with EC₅₀ values of 0.24 and 39.51 μM^[1].
STING agonist-31 (0-10 μM, 24 h) activates the ISG signaling and NF-κB signaling^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

STING agonist-31 (Compound 40) (10 mg/kg, i.v.) inhibits tumor growth in 4T1 and CT26 tumor mice model^[1].
STING agonist-31 (1 mg/kg, i.v., rats) shows T_1/2: 0.697 h, AUC_last: 678 h•ng/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)^[1]
Dosage:

10 mg/kg
Administration:

i.v., at days 1, 4, and 7
Result:

Inhibited tumor Growth.

Chemical Information

CAS No. 2719001-44-0
분자량 873.96
화학식 C₄₃H₅₁N₁₅O₆
SMILES

O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CC(OCCCN4CCOCC4)=C3N2C/C=C/CN5C6=C(OC)C=C(C7=NN=CN7)C=C6N=C5NC(C8=CC(C)=NN8CC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Song Z, et al. Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists. J Med Chem. 2021 Feb 11;64(3):1649-1669. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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