country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-185379

Copy Link Print Information

STING antagonist-3

STING antagonist-3 is a potent STING antagonist with an IC₅₀ of 2.3 nM against human wild-type STING. STING antagonist-3 inhibits human wild-type STING and the gain-of-function STING mutants N154S and V155M. STING antagonist-3 suppresses IFN‑α2a production in stimulated human whole blood. STING antagonist-3 inhibits IP-10 production in activated human dermal microvascular endothelial cells (HMVEC-d). STING antagonist-3 can be used for the research of autoimmune diseases, autoinflammatory diseases, interferonopathies, and fibrotic disorders.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3106554-00-8
화학식: C₃₅H₃₉N₅O₃
분자량:577.72

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

STING antagonist-3 Chemical Structure

CAS No.: 3106554-00-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

STING antagonist-3 (Example 21) inhibits human wild-type STING^R232 with an IC₅₀ of 2.3 nM in the competitive HTRF binding assay^[1].
STING antagonist-3 (100 μM; temperature ramp from 15°C to 95°C over 160 cycles) stabilizes human wild-type STING protein against thermal denaturation with a ΔT_m of 29 K in the DSF assay^[1].
STING antagonist-3 (10 μM; 60 min (pre-incubation); 22 h (post-stimulation)) inhibits cGAMP-stimulated IFNα2α production in human whole blood with an IC₅₀ of 0.029 μM^[1].
STING antagonist-3 (1 h (pre-incubation); 6 h (stimulation)) inhibits dsDNA-stimulated IP-10 production in human HMVEC cells with an IC₅₀ of 6.8 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3106554-00-8
분자량 577.72
화학식 C₃₅H₃₉N₅O₃
SMILES

CC(N=C([C@@H]1CC[C@H](CC1)C(O)=O)C=C2)=C2N3C(C)=C(C(C)C)C(C4=CC=CC5=NN(C[C@H](O)C6=CC=CC=C6)C=C54)=N3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Matthias Hoffmann, et al. Heterocyclic acids as sting antagonists and the use thereof as medicament, WO, WO2025228902A1, 2025-11-06.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기