2. Metabolic Enzyme/Protease
  3. Phosphorylase
  4. m-APTA

m-APTA  (Synonyms: 5′-S-(3-Aminophenyl)-5′-thioadenosine)

Art. -Nr.: HY-W750643 Reinheit: 99.54%
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m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP). m-APTA can be converted into adenine, which is a crucial step in protecting normal cells from the toxicity of nucleobase analogues (NBA). m-APTA is promising for research of MTAP-deficient cancers.

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m-APTA

m-APTA Chemische Struktur

CAS. Nr. : 86072-47-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 Auf Lager
Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
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m-APTA Related Antibodies

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Beschreibung

m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP). m-APTA can be converted into adenine, which is a crucial step in protecting normal cells from the toxicity of nucleobase analogues (NBA). m-APTA is promising for research of MTAP-deficient cancers[1].

Molekulargewicht

374.42

Formel

C16H18N6O3S
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

NC1=CC=CC(SC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=NC(C3=NC=N4)=C4N)O2)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (267.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6708 mL 13.3540 mL 26.7080 mL
5 mM 0.5342 mL 2.6708 mL 5.3416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6708 mL 13.3540 mL 26.7080 mL 66.7699 mL
5 mM 0.5342 mL 2.6708 mL 5.3416 mL 13.3540 mL
10 mM 0.2671 mL 1.3354 mL 2.6708 mL 6.6770 mL
15 mM 0.1781 mL 0.8903 mL 1.7805 mL 4.4513 mL
20 mM 0.1335 mL 0.6677 mL 1.3354 mL 3.3385 mL
25 mM 0.1068 mL 0.5342 mL 1.0683 mL 2.6708 mL
30 mM 0.0890 mL 0.4451 mL 0.8903 mL 2.2257 mL
40 mM 0.0668 mL 0.3338 mL 0.6677 mL 1.6692 mL
50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.3354 mL
60 mM 0.0445 mL 0.2226 mL 0.4451 mL 1.1128 mL
80 mM 0.0334 mL 0.1669 mL 0.3338 mL 0.8346 mL
100 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.6677 mL
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m-APTA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-APTA86072-47-15′-S-(3-Aminophenyl)-5′-thioadenosinePhosphorylaseMTAPadenineMTAP-deficient cancersInhibitorinhibitorinhibit

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