FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

Cytokine. 1999 Oct;11(10):729-35. doi: 10.1006/cyto.1999.0485.

M H Xie ¹, I Holcomb, B Deuel, P Dowd, A Huang, A Vagts, J Foster, J Liang, J Brush, Q Gu, K Hillan, A Goddard, A L Gurney

Affiliations

Affiliation

1 Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

PMID: 10525310 DOI: 10.1006/cyto.1999.0485

Abstract

We have identified a novel Fibroblast Growth Factor, FGF-19, the most distant member of the FGF Family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF Family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.

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