2. Academic Validation
  3. Inhibitory effects of grape seed extract on lipases

Inhibitory effects of grape seed extract on lipases

  • Nutrition. 2003 Oct;19(10):876-9. doi: 10.1016/s0899-9007(03)00167-9.
Diego A Moreno 1,  Nebojsa Ilic,  Alexander Poulev,  Dawn L Brasaemle,  Susan K Fried,  Ilya Raskin
Affiliations

Affiliation

  • 1 Biotech Center, Cook College, Rutgers--The State University of New Jersey, New Brunswick, New Jersey 08901-8520, USA. [email protected]
PMID: 14559324 DOI: 10.1016/s0899-9007(03)00167-9
Abstract

Objective: The aim of the present study was to assess the effects of grape seed extract (GSE) on the fat-metabolizing enzymes pancreatic Lipase, lipoprotein Lipase, and hormone-sensitive Lipase in vitro and evaluate its potential application as a treatment for obesity.

Methods: Crushed grape seeds were extracted in ethanol, and the extract was assayed for the measurement of inhibitory effects on pancreatic Lipase and lipoprotein Lipase activities and on lipolysis of 3T3-L1 adipocytes.

Results: The GSE rich in bioactive phytochemicals showed inhibitory activity on the fat-metabolizing enzymes pancreatic Lipase and lipoprotein Lipase, thus suggesting that GSE might be useful as a treatment to limit dietary fat absorption and the accumulation of fat in adipose tissue. The observed reduction in intracellular lipolytic activity of cultured 3T3-L1 adipocytes may reduce the levels of circulating free fatty acids that have been linked to Insulin resistance in obese patients.

Conclusion: The GSE rich in compounds that inhibit lipases may provide a safe, natural, and cost-effective weight control treatment.

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