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Cat. No.: HY-181919

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CD73-IN-22

CD73-IN-22 (Compound HX-6) is a non-nucleoside CD73 inhibitor with an IC₅₀ of 0.07 μM. When radiolabeled with ⁶⁸Ga, CD73-IN-22 acts as a PET radiotracer for detecting CD73 expression. When radiolabeled with ¹⁷⁷Lu, CD73-IN-22 exhibits anticancer activity against colorectal adenocarcinoma. CD73-IN-22 is applicable to research related to colon adenocarcinoma and breast cancer.

For research use only. We do not sell to patients.

Formula: C₄₃H₄₅FN₁₂O₉
Molecular Weight:892.89

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Please store the product under the recommended conditions in the Certificate of Analysis.

CD73-IN-22 Chemical Structure

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 0.07 μM (CD73)^[1]

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

In Vitro

CD73-IN-22 potently inhibits the enzymatic activity of CD73, with an IC₅₀ of 0.07 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 892.89
Formula C₄₃H₄₅FN₁₂O₉
SMILES

OC(CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(N2N=CC3=C2C=C(N4C(C=C(C5=CC=NN5CC6=CC=C(C#N)C=C6)C=C7F)=C7N=N4)C=C3)=O)C(O)=O)CC1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhao C, et al. Design, synthesis and preclinical evaluation of a tumor extracellular nucleotidase CD73 targeted theranostic radiotracer. Eur J Med Chem. 2026;308:118728. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CD73-IN-22

All Radionuclide-Drug Conjugates (RDCs) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CD73-IN-22 Related Classifications

HY-181919 Related Classifications