Glucagon (22-29)
Based on 1 Customer Validation
Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca2+ pump in liver plasma membranes independently of adenylate cyclase activation.
For research use only. We do not sell to patients.
- Purity: 98.12%
- CAS No.: 32204-93-6
- Formula: C49H71N11O12S
- Molecular Weight:1038.22
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Glucagon (22-29) produces only a 5-15% maximal inhibition of (Ca2+-Mg2+) ATPase, with a low potency (Ki=1 μM), similar to that of native glucagon[1].
Glucagon (22-29) (10 nM) evokes an early small decrease of cell contraction when added alone and an 18% significant positive inotropic effect when added in combination with 30 nM glucagon. Glucagon (22-29) thus appears to act as a partial agonist of miniglucagon[2].
Glucagon (22-29) consists of the COOH-terminal part of miniglucagon but lacks the three Ala1g-Gln20-Asp21 residues[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 32204-93-6
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Appearance Solid
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Molecular Weight 1038.22
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Formula C49H71N11O12S
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Color White to off-white
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Sequence Shortening
FVQWLMNT
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (96.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Mallat A, et al. A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon. Nature. 1987 Feb 12-18;325(6105):620-2. [Content Brief]
[2]. Pavoine C, et al. Miniglucagon [glucagon-(19-29)] is a component of the positive inotropic effect of glucagon. Am J Physiol. 1991 May;260(5 Pt 1):C993-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9632 mL | 4.8159 mL | 9.6319 mL | 24.0797 mL |
| 5 mM | 0.1926 mL | 0.9632 mL | 1.9264 mL | 4.8159 mL | |
| 10 mM | 0.0963 mL | 0.4816 mL | 0.9632 mL | 2.4080 mL | |
| 15 mM | 0.0642 mL | 0.3211 mL | 0.6421 mL | 1.6053 mL | |
| 20 mM | 0.0482 mL | 0.2408 mL | 0.4816 mL | 1.2040 mL | |
| 25 mM | 0.0385 mL | 0.1926 mL | 0.3853 mL | 0.9632 mL | |
| 30 mM | 0.0321 mL | 0.1605 mL | 0.3211 mL | 0.8027 mL | |
| 40 mM | 0.0241 mL | 0.1204 mL | 0.2408 mL | 0.6020 mL | |
| 50 mM | 0.0193 mL | 0.0963 mL | 0.1926 mL | 0.4816 mL | |
| 60 mM | 0.0161 mL | 0.0803 mL | 0.1605 mL | 0.4013 mL | |
| 80 mM | 0.0120 mL | 0.0602 mL | 0.1204 mL | 0.3010 mL |
Glucagon (22-29) Related Classifications
HY-P3617 Related Classifications
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