Anti-Mouse CD40L/CD154 Antibody (MR-1)
Based on 1 Customer Validation
Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for researches on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis.
For research use only. We do not sell to patients.
- Purity: 99.62%
- Molecular Weight:146.76 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Armenian hamster IgG
Mouse
CD40L/CD154
Anti-Mouse CD40L/CD154 Antibody (MR-1) (200 μg/mL, 48 h) significantly inhibits the production of IFN-β in natural killer T (NKT) cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NKT cells, co-cultivation with peritoneal macrophages
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Concentration:200 μg/mL
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Incubation Time:48 h
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Result:Reduced the level of IFN-β.
Anti-Mouse CD40L/CD154 Antibody (MR-1) (20 mg/kg, i.p., once daily for 4 days at 1 day before surgery, once a week until the end of the experiment) extends the survival time of human neural stem cells (hNSCs) in 5XFAD transgenic mice[2].
Anti-Mouse CD40L/CD154 Antibody (MR-1) (25 mg/kg, i.p., on day 0, 2, 4 and 7 for initial stage, once weekly for maintenance stage) can temporarily delay the progression of cholangitis in dnTGFβRII mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:1×104 KPC1242 cells injected male C57BL/6J mice (8-12 weeks)[1]
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Dosage:500 μg
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Administration:Intraperitoneal injection (i.p.), once every 2 days, from 2 days before tumor inoculation to 12 days after inoculation
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Result:Significantly reduced the expression of IFN signaling pathway.
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Animal Model:5XFAD transgenic mice[2]
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Dosage:20 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily for 4 days at 1 day before surgery, once a week until the end of the experiment
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Result:Extended the survival time of hNSCs to 34 weeks.
Significantly suppressed transplant rejection reaction.
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Animal Model:dnTGFβRII mice (3-4 weeks)[3]
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Dosage:25 mg/kg
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Administration:Intraperitoneal injection (i.p.), on day 0, 2, 4 and 7 for initial stage, once weekly for maintenance stage
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Result:Significantly reduced portal vein inflammation and bile duct injury scores for short-term treatment.
Reduced intrahepatic NKT cells and effector T cells in short-term treatment.
Reduced the levels of IFN-γ, IL-4 and IL-17A for short-term treatment.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay, Research in vivo
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Clinical disease scores of mice with active intestinal inflammation and upon Anti-Mouse CD40L/CD154 Antibody (MR-1, HY-P990134) remission in colitis. -
Histopathological scores of naive mice, mice with active disease, or Anti-Mouse CD40L/CD154 Antibody (MR-1, HY-P990134) in colitis.
Chemical Information
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Appearance Liquid
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Molecular Weight 146.76 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD40L/CD154 Antibody (MR-1)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Li J, et al. Intratumoral NKT cell accumulation promotes antitumor immunity in pancreatic cancer. Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2403917121. [Content Brief]
[2]. Chen KS, et al. Human neural stem cells restore spatial memory in a transgenic Alzheimer's disease mouse model by an immunomodulating mechanism. Front Aging Neurosci. 2023 Dec 14;15:1306004. [Content Brief]
[3]. Tanaka H, et al. Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis. Clin Exp Immunol. 2013 Dec;174(3):364-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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