1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. ONC206

ONC206 

Cat. No.: HY-135147 Purity: 99.72%
Handling Instructions

ONC206 is an analogue of TRAIL inducer ONC201. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity.

For research use only. We do not sell to patients.

ONC206 Chemical Structure

ONC206 Chemical Structure

CAS No. : 1638178-87-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 81 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ONC206 is an analogue of TRAIL inducer ONC201[1]. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity[2].

IC50 & Target

DRD2/3/4[2]

In Vitro

ONC206 selectively antagonizes the D2-like (DRD2/3/4), but not the D1-like (DRD 1/5), subfamily of dopamine receptors[2].
ONC206 significantly inhibits tumor cell migration and invasion in vitro[1].
ONC206 (0.05 μM; Over 48 hours) inhibits migration of ONC201- and TRAIL-resistant HCT116 Bax−/− cells without inducing cell death or inhibiting cell proliferation[1].
ONC206 engages the ISR and TRAIL pathway leading to tumor growth arrest and cell death[1].
ONC206 does not induce cell cycle arrest in a colorectal cell line with acquired ONC201-resistance[1].

Cell Proliferation Assay[1]

Cell Line: HCT116 cells
Concentration: 0.05 μM
Incubation Time: Over 48 hours
Result: Inhibited migration of ONC201- and TRAIL-resistant HCT116 Bax−/− cells.
In Vivo

ONC206 (100 mg/kg;p.o.; every 10 days) causes significant tumor growth inhibition[2].

Molecular Weight

408.44

Formula

C₂₃H₂₂F₂N₄O

CAS No.

1638178-87-6

SMILES

O=C1N(CC2=CC=C(F)C=C2F)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (244.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4483 mL 12.2417 mL 24.4834 mL
5 mM 0.4897 mL 2.4483 mL 4.8967 mL
10 mM 0.2448 mL 1.2242 mL 2.4483 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.25 mg/mL (7.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.25 mg/mL (7.96 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.25 mg/mL (7.96 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ONC206ONC 206ONC-206Dopamine ReceptorONC201DRD2/3/4D2-likedopaminereceptorsantagonistInhibitorinhibitorinhibit

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ONC206
Cat. No.:
HY-135147
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