1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. ONC206

ONC206 

Cat. No.: HY-135147
Handling Instructions

ONC206 is an analogue of TRAIL inducer ONC201. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity.

For research use only. We do not sell to patients.

ONC206 Chemical Structure

ONC206 Chemical Structure

CAS No. : 1638178-87-6

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Description

ONC206 is an analogue of TRAIL inducer ONC201[1]. ONC206 is a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations. ONC206 has broad-spectrum anti-tumor activity[2].

IC50 & Target

DRD2/3/4[2]

In Vitro

ONC206 selectively antagonizes the D2-like (DRD2/3/4), but not the D1-like (DRD 1/5), subfamily of dopamine receptors[2].
ONC206 significantly inhibits tumor cell migration and invasion in vitro[1].
ONC206 (0.05 μM; Over 48 hours) inhibits migration of ONC201- and TRAIL-resistant HCT116 Bax−/− cells without inducing cell death or inhibiting cell proliferation[1].
ONC206 engages the ISR and TRAIL pathway leading to tumor growth arrest and cell death[1].
ONC206 does not induce cell cycle arrest in a colorectal cell line with acquired ONC201-resistance[1].

Cell Proliferation Assay[1]

Cell Line: HCT116 cells
Concentration: 0.05 μM
Incubation Time: Over 48 hours
Result: Inhibited migration of ONC201- and TRAIL-resistant HCT116 Bax−/− cells.
In Vivo

ONC206 (100 mg/kg;p.o.; every 10 days) causes significant tumor growth inhibition[2].

Molecular Weight

408.44

Formula

C₂₃H₂₂F₂N₄O

CAS No.

1638178-87-6

SMILES

O=C1N(CC2=CC=C(F)C=C2F)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ONC206ONC 206ONC-206Dopamine ReceptorONC201DRD2/3/4D2-likedopaminereceptorsantagonistInhibitorinhibitorinhibit

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