2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. ONO-2921

ONO-2921 is an orally active and selective N-type calcium channel blocker. ONO-2921 functionally blocks N-type calcium channels. ONO-2921 reduces paw withdrawal responses during persistent nociception and hyperalgesia to heat in neuropathic pain models. ONO-2921 can be used for research on neuropathic pain and nociceptive pain.

For research use only. We do not sell to patients.

ONO-2921

ONO-2921 Chemical Structure

CAS No. : 253306-39-7

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ONO-2921 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

ONO-2921 is an orally active and selective N-type calcium channel blocker. ONO-2921 functionally blocks N-type calcium channels. ONO-2921 reduces paw withdrawal responses during persistent nociception and hyperalgesia to heat in neuropathic pain models. ONO-2921 can be used for research on neuropathic pain and nociceptive pain[1].

In Vitro

ONO-2921 (compound 9) inhibits N-type calcium channels in IMR-32 human neuroblastoma cells with an IC50 of 0.33 μM, and exhibits 15-fold selectivity over L-type calcium channels in AtT-20 mouse pituitary tumor-derived cells[1].
ONO-2921 (3 μM) inhibits 76% of N-type calcium channel currents in IMR-32 human neuroblastoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ONO-2921 Related Antibodies
In Vivo

ONO-2921 (10 mg/kg; p.o.; single administration) exerts significant analgesic effects in the rat formalin-induced pain model[1].
ONO-2921 (30 mg/kg; p.o.; single administration) produces significant analgesic effects in the rat CCI neuropathic pain model[1].
ONO-2921 (100 mg/kg; p.o.; single administration) causes no significant cardiovascular or neurological side effects in healthy brown rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats treated formalin[1]
Dosage: 10 mg/kg
Administration: p.o.; single dose
Result: Significantly inhibited paw flinching during the persistent nociceptive phase .
Animal Model: Rats with chronic constriction injury (CCI)[1]
Dosage: 30 mg/kg
Administration: p.o.; single dose
Result: Exhibited significant antinociceptive effects on thermal hyperalgesia induced by sciatic nerve CCI.
Molecular Weight

604.87

Formula

C31H48N4O4S2
CAS No.
SMILES

O=C(NC1CCN(CC1)CC2=CC=CC=C2)[C@H](CSCC3CCCCC3)NC([C@H]4N(CSC4)C(OC(C)(C)C)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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ONO-2921 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONO-2921253306-39-7ONO2921ONO 2921Calcium ChannelCa2+ channelsCa channelsratsL-type calcium channelsrat CCI neuropathic pain modelthermal hyperalgesianeuropathic painIMR-32 human neuroblastoma cellsnociceptive painAtT-20 mouse pituitary tumor-derived cellsN-type calcium channelsrat formalin-induced pain modelInhibitorinhibitorinhibit

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