Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats

The dimethyl ester of L-glutamic acid (DMG) stimulates Insulin release and was proposed as a possible insulinotropic tool in the treatment of non-insulin-dependent diabetes. In such a perspective, it was investigated whether DMG enhances the B-cell secretory response to GLP-1 in fed anaesthetized rats. The primed constant infusion of DMG (1.0 micromol and then 0.5 micromol/min, both per g body wt.) provoked a rapid and sustained increase in plasma Insulin concentration and augmented the release of Insulin caused by GLP-1. Thus, DMG indeed appears as a suitable tool to potentiate the insulinotropic action of GLP-1.