Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase

  • Bioorg Med Chem Lett. 2001 Dec 3;11(23):3085-8. doi: 10.1016/s0960-894x(01)00635-7.
C Chamorro  1 ,  E Lobatón ,  M C Bonache ,  E De Clercq ,  J Balzarini ,  S Velázquez ,  A San-Félix ,  M J Camarasa
Affiliations
  • 1. Instituto de Química Médica (C.S.I.C.), Juan de la Cierva 3, 28006-Madrid, Spain.
PMID: 11714616 DOI: 10.1016/s0960-894x(01)00635-7
Abstract

N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.