Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

  • Bioorg Med Chem Lett. 2006 Jun 1;16(11):2996-9. doi: 10.1016/j.bmcl.2006.02.060.
Jin Hee Ahn  1 ,  Seung Jun Kim ,  Woul Seong Park ,  Sung Yun Cho ,  Jae Du Ha ,  Sung Soo Kim ,  Seung Kyu Kang ,  Dae Gwin Jeong ,  Suk-Kyeong Jung ,  Sang-Hyeup Lee ,  Hwan Mook Kim ,  Song Kyu Park ,  Ki Ho Lee ,  Chang Woo Lee ,  Seong Eon Ryu ,  Joong-Kwon Choi
Affiliations
  • 1. Bio-Organic Science Division, Korea Research Institute of Chemical Technology, 100 Jang-Dong, Yuseong-Gu, Daejeon 305-343, Republic of Korea.
PMID: 16530413 DOI: 10.1016/j.bmcl.2006.02.060
Abstract

A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.

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