Tyrosinase inhibitors and sesquiterpene diglycosides from Guioa villosa

  • Planta Med. 2008 Jan;74(1):55-60. doi: 10.1055/s-2007-993780.
Abdulmagid Alabdul Magid  1 ,  Laurence Voutquenne-Nazabadioko ,  Geoffroy Bontemps ,  Marc Litaudon ,  Catherine Lavaud
Affiliations
  • 1. Laboratoire de Pharmacognosie, CNRS FRE 2715, IFR53 Biomolécules, Université de Reims Champagne-Ardenne, Reims, France.
PMID: 18203056 DOI: 10.1055/s-2007-993780
Abstract

Through a bioassay-guided phytochemical investigation involving mushroom Tyrosinase inhibitory activity, seven farnesyl diglycosides ( 1 - 7), five Flavonoids ( 8 - 12), one trimeric proanthocyanidin ( 13), two Triterpenes ( 14 and 15), and one cerebroside ( 16), were isolated from the leaves of Caledonian Guioa villosa. Among them, crenulatosides E, F and G ( 1 - 3) were new acyclic sesquiterpene diglycosides. The sesquiterpene diglycosides isolated from the active EtOAc extract showed no inhibitory activity, whereas betulin ( 14), lupeol ( 15) and soyacerebroside I ( 16) demonstrated a potent Tyrosinase inhibitory activity.

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