Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs

  • Bioorg Med Chem. 2011 Dec 1;19(23):7093-9. doi: 10.1016/j.bmc.2011.10.002.
Shuang-Xi Gu  1 ,  Shi-Qiong Yang ,  Qiu-Qin He ,  Xiao-Dong Ma ,  Fen-Er Chen ,  Hui-Fang Dai ,  Erik De Clercq ,  Jan Balzarini ,  Christophe Pannecouque
Affiliations
  • 1. Department of Chemistry, Fudan University, Shanghai 200433, People's Republic of China.
PMID: 22037050 DOI: 10.1016/j.bmc.2011.10.002
Abstract

A series of 18 cycloalkyl arylpyrimidines (CAPYs) were designed from lead compounds diarylpyrimidines (DAPYs), synthesized and evaluated for in vitro anti-HIV activity. Among them, the compound 1p displayed potent anti-HIV-1 activity against WT HIV-1 with an EC(50) value of 0.055 μM and a selectivity index (SI) >7290. The preliminary structure-activity relationship (SAR) of this new series of compounds was also investigated, which enriched the SAR of diarylpyrimidines (DAPYs).