Synthesis of C3-arylated-3-deazauridine derivatives with potent anti-HSV-1 activities

  • Bioorg Med Chem Lett. 2012 Dec 15;22(24):7461-4. doi: 10.1016/j.bmcl.2012.10.047.
Julien Lalut  1 ,  Ludovic Tripoteau ,  Christel Marty ,  Hugo Bares ,  Nathalie Bourgougnon ,  François-Xavier Felpin
Affiliations
  • 1. Université Bordeaux 1, UMR CNRS 5255, Institut des Sciences Moléculaires, 351 Cours de la Libération, 33405 Talence Cedex, France.
PMID: 23141915 DOI: 10.1016/j.bmcl.2012.10.047
Abstract

A series of 3-deazauridines (3-DU) analogues were synthesized and evaluated in vitro for their antiherpetic activity against HSV-1 on Vero cell lines by cell viability. A first campaign of tests suggested that C3-arylated-3-DU derivatives could constitute a novel family of antiherpetic agents. A second campaign of biological evaluations led to the discovery of two potent anti-HSV-1 agents with comparable activity than acyclovir.