Nitrogen-containing bibenzyls from Pleione bulbocodioides: absolute configurations and biological activities

  • Fitoterapia. 2015 Apr:102:120-6. doi: 10.1016/j.fitote.2015.01.015.
Yuan Li  1 ,  Fan Zhang  1 ,  Ze-Hong Wu  1 ,  Ke-Wu Zeng  1 ,  Chen Zhang  1 ,  Hong-Wei Jin  1 ,  Ming-Bo Zhao  1 ,  Yong Jiang  1 ,  Jun Li  2 ,  Peng-Fei Tu  3
Affiliations
  • 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • 2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: [email protected].
  • 3. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: [email protected].
PMID: 25647325 DOI: 10.1016/j.fitote.2015.01.015
Abstract

Four new pyrrolidone substituted bibenzyls, dusuanlansins A-D (1-4) were isolated from the pseudo bulbs of Pleione bulbocodioides, along with 19 known compounds (5-23). Compounds 1-4 are two pairs of epimers of pyrrolidone substituted bibenzyls, which were separated successfully by a Chiralcel OD-RH C18 column. Their absolute configurations were elucidated by calculated ECD. Biological investigations showed that compounds 5 and 7 exhibited potent anti-inflammatory activities on LPS-stimulated NO production in BV-2 microglial cells, with IC50 values of 2.46 and 3.14μM, respectively.

Keywords
Anti-inflammatory activity; Bibenzyl; ECD; Epimer; Pleione bulbocodioides.
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