Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)

  • Nat Prod Res. 2017 Sep;31(17):1981-1987. doi: 10.1080/14786419.2016.1269097.
Ghislain Wabo Fotso  1 ,  Justin Kamga  1 ,  Bathelemy Ngameni  2 ,  Shota Uesugi  3 ,  Misa Ohno  3 ,  Ken-Ichi Kimura  3 ,  Hiroyuki Momma  4 ,  Eunsang Kwon  4 ,  Hiroshi Furuno  5 ,  Yoshihito Shiono  6 ,  Simo K Ingrid  7 ,  Samuel O Yeboah  8 ,  Bonaventure T Ngadjui  1  2
Affiliations
  • 1. a Faculty of Science, Department of Organic Chemistry , University of Yaoundé I , Yaoundé , Cameroon.
  • 2. b Faculty of Medicine and Biomedical Science, Department of Pharmacognosy and Pharmaceutical Sciences , University of Yaoundé I , Yaoundé , Cameroon.
  • 3. c Laboratory of chemical Biology, The United Graduate School of Agricultural Sciences , Iwate University , Morioka , Japan.
  • 4. d Research and Analytical Center for giant Molecules, Graduate School of Science , Tohoku University , Sendai , Japan.
  • 5. e Green Asia Education Center , Kyushu University , Fukuoka , Japan.
  • 6. f Faculty of Agriculture, Department of Food, Life, and Environmental Science , Yamagata University , Tsuruoka , Japan.
  • 7. g Faculty of Science, Department of Chemistry , University of Dschang , Dschang , Cameroon.
  • 8. h Faculty of Science, Department of Chemistry , University of Botswana , Gaborone , Botswana.
PMID: 28103742 DOI: 10.1080/14786419.2016.1269097
Abstract

A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3',4', 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1-6 were assayed for their antiproliferative effects on two human Cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50 of 4.6 μM on HeLa.

Keywords
Albizia glaberrima var glabrescens Oliv.; Albiziaflavan B; antiproliferative effects; butin; chondrillasterone; fustin.
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