Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2

  • J Ginseng Res. 2017 Apr;41(2):127-133. doi: 10.1016/j.jgr.2016.02.001.
Tao Yu  1  2 ,  Yanyan Yang  1  2 ,  Yi-Seong Kwak  3 ,  Gwan Gyu Song  4 ,  Mi-Yeon Kim  5 ,  Man Hee Rhee  6 ,  Jae Youl Cho  1
Affiliations
  • 1. Department of Genetic Engineering, Sungkyunkwan University, Suwon, Korea.
  • 2. Institute of Translational Medicine, Qingdao University, Qingdao, China.
  • 3. Korean Ginseng Corporation, Central Research Institute, Daejeon, Korea.
  • 4. Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
  • 5. Department of Bioinformatics and Life Science, Soongsil University, Seoul, Korea.
  • 6. College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.
PMID: 28413316 DOI: 10.1016/j.jgr.2016.02.001
Abstract

Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including Anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects.

Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-α/interferon-γ-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation.

Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-α and interleukin-1β. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells.

Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.

Keywords
Panax ginseng; TANK-binding kinase 1; anti-inflammatory activity; ginsenoside Rc; p38.
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