Inhibitory effects of homoharringtonine on foot and mouth disease virus in vitro

  • J Med Virol. 2019 Sep;91(9):1595-1601. doi: 10.1002/jmv.25494.
Mei-Jiao Gong  1  2 ,  Shi-Fang Li  2 ,  Yin-Li Xie  2 ,  Fu-Rong Zhao  2 ,  Jun-Jun Shao  2 ,  Yong-Guang Zhang  2 ,  Wen-Hui Wang  1 ,  Hui-Yun Chang  2
Affiliations
  • 1. College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.
  • 2. State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
PMID: 31032977 DOI: 10.1002/jmv.25494
Abstract

Foot-and-mouth disease (FMD) is a highly contagious disease that affects cloven-hoof Animals including cattle, swine, sheep, goats, and lots of wild species. Effectively control measures are urged needed. Here, we showed that homoharringtonine treatment exhibited a strong inhibitory effect against two different strains of FMDVs (O/MYA98/BY/2010 and A/GD/MM/2013) in swine kidney (IBRS-2) cells. Further experiments demonstrated that homoharringtonine did not affect virus attachment or entry. Using time-of-addition assays, we found that the Antiviral activity of homoharringtonine occurred primarily during the early stage of Infection. These results demonstrated that homoharringtonine might be an effective anti-FMDV drug. Further studies are required to explore the Antiviral activity of homoharringtonine against FMDV replication in vivo.

Keywords
FMDV; RNA virus; antiviral; homoharringtonine; viral replication.
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