Mangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir - resistant herpes simplex virus 1 infection

  • Bioorg Med Chem. 2020 Feb 15;28(4):115304. doi: 10.1016/j.bmc.2020.115304.
Daniele Zendrini Rechenchoski  1 ,  Karoline Fontana Agostinho  2 ,  Ligia Carla Faccin-Galhardi  2 ,  Audrey Alesandra Stinghen Garcia Lonni  3 ,  João Vinícius Honório da Silva  4 ,  Fábio Goulart de Andrade  4 ,  Arcelina Pacheco Cunha  5 ,  Nágila Maria Pontes Silva Ricardo  5 ,  Carlos Nozawa  2 ,  Rosa Elisa Carvalho Linhares  6
Affiliations
  • 1. Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, Paraná, Brazil; Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
  • 2. Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
  • 3. Departamento de Ciências Farmacêuticas, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
  • 4. Departamento de Histologia, Universidade Estadual de Londrina, Londrina, Paraná, Brazil.
  • 5. Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
  • 6. Departamento de Microbiologia, Universidade Estadual de Londrina, Londrina, Paraná, Brazil. Electronic address: [email protected].
PMID: 31956052 DOI: 10.1016/j.bmc.2020.115304
Abstract

Mangiferin is found in many plant species as the mango tree (Mangifera indica) with ethnopharmacological applications and scientific evidence. The emergence of resistant herpes simplex virus (HSV) strains to Acyclovir (ACV) has encouraged the search for new drugs. We investigated the in vitro and in vivo activity of mangiferin obtained from M. indica against ACV-resistant HSV-1 (AR-29) and sensitive (KOS) strains. The in vitro activity was performed under varying treatment protocols. The substance showed a CC50 > 500 μg/mL and IC50 of 2.9 μg/mL and 3.5 μg/mL, respectively, for the AR-29 and KOS strains. The in vivo activity was performed in Balb/c mice treated with 0.7% topical mangiferin formulation. This formulation inhibited most effectively the AR-29 strain, attenuated the lesions, postponed their appearance or enhanced healing, in comparison to control group. We demonstrated the potentiality of mangiferin from M. indica to control HSV replication with emphasis to ACV-resistant Infection.

Keywords
Acyclovir-Resistance; Antiviral; HSV; Mangifera indica; Mangiferin.