Anti-HIV Compounds from the Deep-Sea-Derived Fungus Chaetomium globosum

  • Chem Biodivers. 2022 Jan;19(1):e202100804. doi: 10.1002/cbdv.202100804.
Hong-Qiang Hu  1 ,  Yan-Hui Li  2  3 ,  Zuo-Wang Fan  3 ,  Wei-Li Yan  1 ,  Zhi-Hui He  3 ,  Tian-Hua Zhong  3 ,  Ying-Bao Gai  3 ,  Xian-Wen Yang  3
Affiliations
  • 1. The Emergency Department, Army 73rd Group Military Hospital, Chenggong Hospital, Xiamen University), Xiamen, 361003, China.
  • 2. College of Horticulture, Shenyang Agricultural University, 120 Dongling Road, Shenyang, 110866, China.
  • 3. Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005, China.
PMID: 34799976 DOI: 10.1002/cbdv.202100804
Abstract

Chemical investigation on the deep-sea-derived fungus Chaetomium globosum led to the isolation of nine compounds. By extensive analyses of the 1D and 2D NMR as well as HR-ESI-MS spectra, their structures were elucidated as xylariol A (1), 1,3-dihydro-4,5,6-trihydroxy-7-methylisobenzofuran (2), epicoccone B (3), epicoccolide B (4), chaetoglobosin G (5), chaetoglobosin Fex (6), cochliodone A (7), cochliodone B (8), and chaetoviridin A (9), assorting as four phenolics (1-4), two cytochalosans (5-6), and three azaplilones (7-9). Compounds 1-3 were firstly reported from C. globosum. Under the concentrations of 20 μg/mL, 1, 2, and 3 exhibited potent in vitro anti-HIV activity with the inhibition rates of 70 %, 75 %, and 88 %, respectively.

Keywords
Chaetomium globosum; anti-HIV; deep-sea; fungus; phenolics.
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