ALDOA maintains NLRP3 inflammasome activation by controlling AMPK activation

  • Autophagy. 2022 Jul;18(7):1673-1693. doi: 10.1080/15548627.2021.1997051.
Dongsheng Bai  1 ,  Jiaying Du  1 ,  Xiumin Bu  1 ,  Wangjia Cao  1 ,  Tifan Sun  1 ,  Jiawei Zhao  1 ,  Yue Zhao  1 ,  Na Lu  1
Affiliations
  • 1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
PMID: 34821530 DOI: 10.1080/15548627.2021.1997051
Abstract

ALDOA: aldolase A; AMPK: AMP-activated protein kinase; ATG: Autophagy related; ATG5: Autophagy related 5; ATP: adenosine triphosphate; BMDMs: bone marrow-derived macrophages; CALCOCO2: calcium binding and coiled-coil domain 2; CASP1: Caspase 1; CQ: chloroquine; FOXO3: forkhead box O3; IL1B: interleukin 1 beta; LPS: lipopolysaccharide; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MT: mutant; mtDNA: mitochondrial DNA; MTORC1: mechanistic target of rapamycin kinase complex 1; mtROS: mitochondrial reactive oxygen species; NLRP3: NLR family, pyrin domain containing 3; OPTN: optineurin; PBS: phosphate-buffered saline; PRKN/Parkin: parkin RBR E3 ubiquitin protein ligase; SN: supernatant; SQSTM1/p62: sequestosome 1; STK11/LKB1: serine/threonine kinase 11; TOMM20: translocase of outer mitochondrial membrane 20; ULK1: unc-51 like Autophagy activating kinase 1; v-ATPase: vacuolar type H+-ATPase; WT: wild-type.

Keywords
ALDOA; AMPK; LYG-202; NLRP3 inflammasome; mitophagy.
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