Cyclophilin E (CypE) Functions as a Positive Regulator in Osteoblast Differentiation by Regulating the Transcriptional Activity of Runx2

  • Cells. 2023 Oct 31;12(21):2549. doi: 10.3390/cells12212549.
Meiyu Piao  1 ,  Sung Ho Lee  1 ,  Yuankuan Li  1 ,  Joong-Kook Choi  2 ,  Chang-Yeol Yeo  3 ,  Kwang Youl Lee  1
Affiliations
  • 1. College of Pharmacy, Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju 61186, Republic of Korea.
  • 2. Division of Biochemistry, College of Medicine, Chungbuk National University, Cheong-Ju 28644, Republic of Korea.
  • 3. Department of Life Science and Research Center for Cellular Homeostasis, Ewha Woman's University, Seoul 03760, Republic of Korea.
PMID: 37947627 DOI: 10.3390/cells12212549
Abstract

Cyclophilin E (CypE) belongs to the Cyclophilin family and exhibits peptidyl-prolyl cis-trans isomerase (PPIase) activity. It participates in various biological processes through the regulation of peptidyl-prolyl isomerization. However, the specific role of CypE in osteoblast differentiation has not yet been elucidated. In this study, we first discovered the positive impact of CypE on osteoblast differentiation through gain or loss of function experiments. Mechanistically, CypE enhances the transcriptional activity of RUNX2 through its PPIase activity. Furthermore, we identified the involvement of the Akt signaling pathway in CypE's function in osteoblast differentiation. Taken together, our findings indicate that CypE plays an important role in osteoblast differentiation as a positive regulator by increasing the transcriptional activity of RUNX2.

Keywords
CypE; Runx2; osteoblast differentiation.