Formyl phloroglucinol meroterpenoids from the leaves of Eucalyptus globulus subsp. maidenii and their ATP-citrate lyase inhibitory activities

  • Fitoterapia. 2024 Jan 4:105813. doi: 10.1016/j.fitote.2023.105813.
Zhu Hu  1 ,  Yi-Nan Liu  2 ,  Mei-Hua Yu  1 ,  Ai-Jun Hou  3 ,  Jing-Ya Li  4 ,  Ying-Xia Li  5 ,  Chun Lei  6
Affiliations
  • 1. School of Pharmacy, Fudan University, Shanghai 201203, China.
  • 2. School of Pharmacy, Fudan University, Shanghai 201203, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • 3. School of Pharmacy, Fudan University, Shanghai 201203, China; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
  • 4. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: [email protected].
  • 5. School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: [email protected].
  • 6. School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: [email protected].
PMID: 38184174 DOI: 10.1016/j.fitote.2023.105813
Abstract

Three new formyl phloroglucinol meroterpenoids, eumaidials A-C (1-3), were isolated from the leaves of Eucalyptus globulus subsp. maidenii, along with ten known analogues (4-13). Their chemical structures were determined by various spectral data and electronic circular dichroism calculations. Eumaidial A (1) is the first β-caryophyllene-based formyl phloroglucinol meroterpenoids from the genus Eucalyptus. Compounds 1-4 and 10 exhibited ATP-citrate lyase inhibitory activities, and compounds 2 and 3 suppressed the hepatocyte lipogenesis.

Keywords
ATP-citrate lyase; Eucalyptus globulus subsp. maidenii; Meroterpenoids.
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