Antimicrobial and Antiviral Nanofibers Halt Co-Infection Spread via Nuclease-Mimicry and Photocatalysis

  • Adv Sci (Weinh). 2024 Apr 22:e2309590. doi: 10.1002/advs.202309590.
Jieran Yao  1 ,  Zhenhong Luo  2 ,  Jiaying Lin  1 ,  Na Meng  1 ,  Jiangna Guo  2 ,  Hui Xu  2 ,  Rongwei Shi  3 ,  Linhui Zhao  1 ,  Jiateng Zhou  4 ,  Feng Yan  2 ,  Bin Wang  4 ,  Hailei Mao  1
Affiliations
  • 1. Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
  • 2. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.
  • 3. School of Material and Chemical Engineering, Tongren University, Tongren, 554300, China.
  • 4. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
PMID: 38647392 DOI: 10.1002/advs.202309590
Abstract

The escalating spread of drug-resistant bacteria and viruses is a grave concern for global health. Nucleic acids dominate the drug-resistance and transmission of pathogenic microbes. Here, imidazolium-type poly(ionic liquid)/porphyrin (PIL-P) based electrospun nanofibrous membrane and its cerium (IV) ion complex (PIL-P-Ce) are developed. The obtained PIL-P-Ce membrane exhibits high and stable efficiency in eradicating various Microorganisms (bacteria, fungi, and viruses) and decomposing microbial Antibiotic resistance genes and viral nucleic acids under light. The nuclease-mimetic and photocatalytic mechanisms of the PIL-P-Ce are elucidated. Co-infection wound models in mice with methicillin-resistant S. aureus and hepatitis B virus demonstrate that PIL-P-Ce integrate the triple effects of cationic polymer, photocatalysis, and nuclease-mimetic activities. As revealed by proteomic analysis, PIL-P-Ce shows minimal phototoxicity to normal tissues. Hence, PIL-P-Ce has potential as a "green" wound dressing to curb the spread of drug-resistant bacteria and viruses in clinical settings.

Keywords
antibiotic resistance genes; antimicrobial and antiviral nanofibers; artificial nuclease; photodynamic therapy; poly(ionic liquid); viral nucleic acids.
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