Lycopene
Based on 19 publication(s) in Google Scholar
Lycopene is naturally occurring carotenoids found in tomato, tomato products, and in other red fruits and vegetables; exhibits antioxidant effects.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 502-65-8
- Formula: C40H56
- Molecular Weight:536.87
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Storage:
-80°C, protect from light, stored under nitrogen
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lycopene
More- Adv Sci (Weinh). 2024 Jun;11(24):e2309590. [Abstract]
- Redox Biol. 2020 Sep;36:101601. [Abstract]
- Food Chem. 2026 Mar 4:510:148679. [Abstract]
- Phytomedicine. 2025 Dec 24:150:157740. [Abstract]
- Ecotoxicol Environ Saf. 2025 Sep 15:303:119045. [Abstract]
- Life Sci. 2025 Feb 7:123452. [Abstract]
- Drug Des Devel Ther. 2023 Oct 13:17:3085-3101. [Abstract]
- Int J Mol Sci. 2025 Aug 5;26(15):7560. [Abstract]
- J Funct Foods. 2024 Feb, 113, 106021.
- Sci Rep. 2026 Jan 3;16(1):4293. [Abstract]
- Fish Shellfish Immunol. 2023 Aug:139:108897. [Abstract]
- J Neurosci Res. 2019 Dec;97(12):1689-1705. [Abstract]
- Mol Cell Probes. 2020 Jun;51:101559. [Abstract]
- J Biochem Mol Toxicol. 2025 Feb;39(2):e70158. [Abstract]
- Physiol Behav. 2020 Oct 1;224:113026. [Abstract]
- Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303. [Abstract]
- Arch Oral Biol. 2025 Dec 11:182:106480. [Abstract]
- Arch Oral Biol. 2025 Feb 12:173:106194. [Abstract]
- Journal of Experimental and Clinical Anatomy. 2024 Dec 31.
Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
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Histological Imaging/Staining
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Gel Electrophoresis
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Cell Imaging/Staining
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
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| Platelet | IC50 |
5.8 μM
Compound: Lycopene
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Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
Inhibition of collagen-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
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[PMID: 32463237] |
| Platelet | IC50 |
6.2 μM
Compound: Lycopene
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Inhibition of ADP-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
Inhibition of ADP-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
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[PMID: 32463237] |
| Platelet | IC50 |
6.8 μM
Compound: Lycopene
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Inhibition of arachidonic acid-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
Inhibition of arachidonic acid-induced platelet aggregation in human platelet suspension preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by lumi-aggregometry
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[PMID: 32463237] |
Sufficient uptake of lycopene from the diet is necessary to benefit from its health promoting effects, since humans are unable to synthesise lycopene de novo. Lycopene significantly inhibits prostate and breast cancer cell growth at physiologically relevant concentrations of 1.25 μM and also causes a 30-40 % reduction in inhibitor of kappa B phosphorylation in the cells[1].
Increased intake of lycopene, a major carotenoid in tomatoes, consumed as the all-trans-isomer attenuates alcohol induced apoptosis in 2E1 cells and reduces risk of prostate, lung and digestive cancers. Lycopene plays a role in the protection against photooxidative processes by acting as singlet molecular oxygen and peroxyl radicals scavengers and can interact synergistically with other antioxidants[2].
Lycopene as a carotenoid can react with types of reactive oxygen species (ROS) in three different mechanisms: I) by electron-transfer, II) by hydrogen atom transfer or III) by adduct formation. Lycopene is able to deactivate singlet oxygen mainly by physical quenching[3].
Lycopene decreases ROS production in SK-Hep-1 cells through inhibition of NADPH oxidase, brought about in the PKC pathway[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Lycopene or processed tomatoes may lead to a reduction of intima-media thickness in vessel walls[3].
Lycopene exerts protective effects against ATZ-induced toxicity in rat adrenal cortex. These effects may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway[4].
Lycopene improves hepatotoxicity acting as an antioxidant, reduces GSSG and regulates tGSH and CAT levels, reduces oxidative damage[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 502-65-8
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Appearance Solid
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Molecular Weight 536.87
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Formula C40H56
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Color Purple to red
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SMILES
C/C(C)=C\CC/C(C)=C/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(/C=C/C=C(C)/C=C/C=C(CC/C=C(C)\C)\C)C
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Structure Classification
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Initial Source
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
Publications (19)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Antimicrobial and Antiviral Nanofibers Halt Co-Infection Spread via Nuclease-Mimicry and Photocatalysis. [Abstract]2024 Jun;11(24):e2309590. PMID: 38647392
Lycopene purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun;11(24):e2309590. [Abstract]
DNA cleavage efficiencies of gel electrophoresis under Lycopene (50 mM) with light for 30 min and subsequently without light till 4 h.
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Redox Biol
An effective inactivant based on singlet oxygen-mediated lipid oxidation implicates a new paradigm for broad-spectrum antivirals. [Abstract]2020 Sep;36:101601. PMID: 32535542
Lycopene purchased from MedChemExpress. Usage Cited in: Redox Biol. 2020 Sep;36:101601. [Abstract]
PK-15 cells were incubated with 50 nM Si-DMA and different concentrations of LJ002. The generation of 1O2 in the absence or presence of 1 μM Lycopene for 1 h was observed with fluorescence microscopy.
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Food Chem
Enhanced carotenoid solubility in organic solvents via trans-cis photoisomerization induced by nanosecond-pulsed laser irradiation. [Abstract]2026 Mar 4:510:148679. PMID: 41802405 -
Phytomedicine
Bruceantin inhibits the c-Myc/RL27A axis to suppress tumor progression in hepatocellular carcinoma. [Abstract]2025 Dec 24:150:157740. PMID: 41477978 -
Ecotoxicol Environ Saf
Lycopene inhibits zearalenone-induced ferroptosis via activating AMPK/Nrf2 signaling pathway in AML-12 hepatocytes and in mice livers. [Abstract]2025 Sep 15:303:119045. PMID: 40945091
Lycopene purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Sep 15:303:119045. [Abstract]
Effect of different concentrations of Lycopene (LYC) (0, 5, 10, 20, 30, 40, 50 μM) on cell viability.
Lycopene purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Sep 15:303:119045. [Abstract]
ZEA decreased the protein levels of GPX4 and FTH1 . Nevertheless, pretreatment with Lycopene (LYC) (20 μM) counteracted these effects induced by ZEA in AML-12 cells.
Lycopene purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Sep 15:303:119045. [Abstract]
Morphological change of liver tissues from each group by HE staining, Lycopene (LYC) (5 mg/kg, i.g.) attenuated ZEA-induced hepatocyte injury in mice.
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Life Sci
Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway. [Abstract]2025 Feb 7:123452. PMID: 39923835 -
Drug Des Devel Ther
Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS). [Abstract]2023 Oct 13:17:3085-3101. PMID: 37854130 -
Int J Mol Sci
2025 Aug 5;26(15):7560. PMID: 40806687 -
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Sci Rep
Lycopene ameliorates intestinal barrier dysfunction following traumatic brain injury by inhibiting pyroptosis. [Abstract]2026 Jan 3;16(1):4293. PMID: 41484441 -
Fish Shellfish Immunol
Lycopene abolishes typical polyhalogenated carbazoles (PHCZs)-induced hepatic injury in yellow catfish (Pelteobagrus fulvidraco): Involvement of ROS/PI3K-AKT/NF-κB signaling. [Abstract]2023 Aug:139:108897. PMID: 37301309 -
J Neurosci Res
Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein. [Abstract]2019 Dec;97(12):1689-1705. PMID: 31420910 -
Mol Cell Probes
Lycopene alleviates disc degeneration under oxidative stress through the Nrf2 signaling pathway. [Abstract]2020 Jun;51:101559. PMID: 32151764 -
J Biochem Mol Toxicol
Lycopene Ameliorates Polycystic Ovary Syndrome in Rats by Inhibiting Ovarian Ferroptosis Through Activation of the AMPK/Nrf2 Pathway. [Abstract]2025 Feb;39(2):e70158. PMID: 39871526 -
Physiol Behav
Lycopene ameliorates PTSD-like behaviors in mice and rebalances the neuroinflammatory response and oxidative stress in the brain. [Abstract]2020 Oct 1;224:113026. PMID: 32592701 -
Biochem Biophys Res Commun
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]2018 Sep 3;503(1):297-303. PMID: 29890135 -
Arch Oral Biol
Exploring the relationship between gut microbiota-metabolite axis and Jiawei Danxuan Koukang's therapeutic effects in male rats with oral submucous fibrosis: A multi-omics analysis. [Abstract]2025 Dec 11:182:106480. PMID: 41401479 -
Arch Oral Biol
Jiawei Danxuan Koukang and its key component Quercetin intervened in OSF carcinogenesis by inhibiting the AR/eIF5A2 signaling pathway-mediated EMT. [Abstract]2025 Feb 12:173:106194. PMID: 39961149 -
Solvent & Solubility
THF : 5 mg/mL (9.31 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
PC3 cells and MDA-MB-231 cells are treated with (0, 0.5, 1.25, 2.5 and 5 μM) lycopene for 48 h. Cell survival/growth is measured using the colorimetric MTS assay method. MTS-PMS complex (20 μL) is added to each well. The catalytic activity of viable cells results in formazan dye production, which is then quantified. Cells are incubated with the dye for 1 h, followed by absorbance reading at 492 nm on a spectrophotometer[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Rats: Lycopene is dissolved in corn oil. 35 adult male albino rats are randomized into five equal groups: untreated control, vehicle control (receives 0.5 mL corn oil/day), lycopene (10 mg/kg b.w./day), ATZ (dissolved in 0.5 mL corn oil 300 mg/kg b.w./day), and ATZ + lycopene. All treatments are given by oral gavage for 4 weeks[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Assar EA, et al. Lycopene acts through inhibition of IκB kinase to suppress NF-κB signaling in human prostate and breast cancer cells. Tumour Biol. 2016 Jul;37(7):9375-85. [Content Brief]
[2]. Tapiero H, et al. The role of carotenoids in the prevention of human pathologies. Biomed Pharmacother. 2004 Mar;58(2):100-10. [Content Brief]
[3]. Müller L, et al. Lycopene and Its Antioxidant Role in the Prevention of Cardiovascular Diseases-A Critical Review. Crit Rev Food Sci Nutr. 2016 Aug 17;56(11):1868-79. [Content Brief]
[4]. Abass MA, et al. Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway. Environ Sci Pollut Res Int. 2016 Aug;23(15):15262-74. [Content Brief]
[5]. Bandeira AC, et al. Lycopene inhibits reactive oxygen species production in SK-Hep-1 cells and attenuates acetaminophen-induced liver injury in C57BL/6 mice. Chem Biol Interact. 2017 Feb 1;263:7-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| THF | 1 mM | 1.8626 mL | 9.3132 mL | 18.6265 mL | 46.5662 mL |
| 5 mM | 0.3725 mL | 1.8626 mL | 3.7253 mL | 9.3132 mL |
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