Two new gingerol derivatives from the rhizome of Curcuma xanthorrhiza D.Dietr

  • Nat Prod Res. 2025 Sep 21:1-11. doi: 10.1080/14786419.2025.2562597.
Hai Xuan Nguyen  1  2  3 ,  Don Thi Truong  1  2 ,  Thang Quoc Truong  1  2  3 ,  Minh Binh Nguyen  1  2  3 ,  Truong Nhat Van Do  1  2  3 ,  Tho Huu Le  1  2  3 ,  Mai Thanh Thi Nguyen  1  2  3 ,  Nhan Trung Nguyen  1  2  3
Affiliations
  • 1. Faculty of Chemistry, University of Science, Ho Chi Minh City, Vietnam.
  • 2. Vietnam National University, Ho Chi Minh City, Vietnam.
  • 3. Research Lab for Drug Discovery and Development, University of Science, Ho Chi Minh City, Vietnam.
PMID: 40975864 DOI: 10.1080/14786419.2025.2562597
Abstract

A phytochemical investigation of the EtOAc-soluble extract from the rhizomes of Curcuma xanthorrhiza D.Dietr. led to the isolation of five gingerol derivatives, including two news, xanthorrhiza A (3) and xanthorrhiza B (5). These compounds were purified through column chromatography, and their structures were elucidated through spectral analysis. Bioactivity testing revealed that xanthorrhiza B (5) exhibited the strongest Tyrosinase inhibitory activity with an IC50 value of 61.0 μM, as strong as a positive control, kojic acid (IC50: 44.6 µM). Additionally, the α-glucosidase inhibitory activity of 8-dehydrogingerdione (2) was the most potent than that of evaluated compounds, with an IC50 value of 19.5 μM, and more potent than a positive control, acarbose (IC50: 185.2 μM).

Keywords
Curcuma xanthorrhiza; gingerol derivatives; tyrosinase; α-glucosidase.
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