[8]-Dehydrogingerdione
[8]-Dehydrogingerdione is a Hydroxyphenylalkanone. [8]-Dehydrogingerdione can be isolated from the seeds of Aframomum melegueta and the rhizomes of Curcuma xanthorrhia. [8]-Dehydrogingerdione acts as an inhibitor of α-glucosidase and Tyrosinase, with an IC50 value of 19.5 μM against α-glucosidase and an approximate IC50 value of 100 μM against tyrosinase. [8]-Dehydrogingerdione can be used in diabetes-related research.
For research use only. We do not sell to patients.
- CAS No.: 77334-08-8
- Formula: C19H26O4
- Molecular Weight:318.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![[8]-Dehydrogingerdione Chemical Structure](https://file.medchemexpress.com/product_pic/hy-n19646.gif "Click to View [8]-Dehydrogingerdione Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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α‑glucosidase 19.5 μM (IC50) |
Tyrosinase 100 μM (IC50) |
[8]-Dehydrogingerdione (1.0-100 μM; 30 min) moderately inhibits mushroom tyrosinase, with an IC50 value of approximately 100 μM[1].
[8]-Dehydrogingerdione (1-100 μM; 30 min) potently inhibits α-glucosidase from Saccharomyces cerevisiae, with an IC50 value of 19.5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 77334-08-8
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Molecular Weight 318.41
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Formula C19H26O4
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SMILES
CCCCCCCC(CC(/C=C/C1=CC(OC)=C(C=C1)O)=O)=O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nguyen HX, et al. Two new gingerol derivatives from the rhizome of Curcuma xanthorrhiza D.Dietr. Nat Prod Res. 2025 Sep 21:1-11. [Content Brief]
[2]. El-Halawany AM, et al. Protective effect of Aframomum melegueta phenolics against CCl₄-induced rat hepatocytes damage; role of apoptosis and pro-inflammatory cytokines inhibition. Sci Rep. 2014;4:5880. Published 2014 Jul 30. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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