CNDP2 Protein, Human (His)
The CNDP2 protein is a catalyst that coordinates the oxidative cleavage of heme at the α-methylene bridge carbon, releasing carbon monoxide (CO) and generating biliverdin IXalpha. This enzymatic process releases ferrous iron from the central heme iron chelate. CNDP2 Protein, Human (His) is the recombinant human-derived CNDP2 protein, expressed by E. coli , with N-His labeled tag.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
The CNDP2 protein is a catalyst that coordinates the oxidative cleavage of heme at the α-methylene bridge carbon, releasing carbon monoxide (CO) and generating biliverdin IXalpha. This enzymatic process releases ferrous iron from the central heme iron chelate. CNDP2 Protein, Human (His) is the recombinant human-derived CNDP2 protein, expressed by E. coli , with N-His labeled tag.
HO-2/HMOX2 protein serves as a catalyst in the oxidative cleavage of heme at the alpha-methene bridge carbon, liberating carbon monoxide (CO) and producing biliverdin IXalpha. This enzymatic process results in the release of the central heme iron chelate as ferrous iron. HO-2/HMOX2 plays a crucial role in the breakdown of heme, facilitating the controlled generation of signaling molecules such as CO and biliverdin. The release of CO, in particular, has various physiological implications, contributing to vascular homeostasis, anti-inflammatory responses, and cellular protection. This enzyme's activity is integral to the regulation of heme metabolism and the maintenance of cellular redox balance.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
Q96KP4-1 (A2-D475)
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Gene ID55748
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Molecular Construction
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N-term
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6*His
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CNDP2 (2-D475)
Accession # Q96KP4-1 -
C-term
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Protein Length
Full Length of Isoform-1 Mature Protein
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Synonyms
Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Peptidase A; CN2; CPGL; HEL-S-13; PEPA
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AA Sequence
AALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFARKDTFFKDVDYVCISDNYWLGKKKPCITYGLRGICYFFIEVECSNKDLHSGVYGGSVHEAMTDLILLMGSLVDKRGNILIPGINEAVAAVTEEEHKLYDDIDFDIEEFAKDVGAQILLHSHKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPNMTPEVVGEQVTSYLTKKFAELRSPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYEVSQLKD
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Predicted Molecular Mass
56.7kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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