CNDP2 Protein, Human (His)
CNDP2 is a cytosolic metallodipeptidase with broad substrate specificity that catalyzes the hydrolysis of amide bonds in dipeptides and peptidomimetics. Its substrates include L-cysteinylglycine, an intermediate metabolite of the γ-glutamyl cycle in glutathione metabolism. CNDP2 Protein, Human (His) is the recombinant human-derived CNDP2 protein, expressed by E. coli , with N-His labeled tag.
- Species: Human
- Source: E. coli
-
Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Help & FAQs
Biological Activity
Description
CNDP2 is a cytosolic metallodipeptidase with broad substrate specificity that catalyzes the hydrolysis of amide bonds in dipeptides and peptidomimetics. Its substrates include L-cysteinylglycine, an intermediate metabolite of the γ-glutamyl cycle in glutathione metabolism. CNDP2 Protein, Human (His) is the recombinant human-derived CNDP2 protein, expressed by E. coli , with N-His labeled tag.
Background
The CNDP2 protein exhibits unique functionality in catalyzing the hydrolysis of peptide bonds in dipeptides, particularly threonyl dipeptides. It plays a tissue-specific role in the catabolism of threonyl dipeptides. Furthermore, CNDP2 displays significant dipeptidase activity toward cysteinylglycine (an intermediate in glutathione metabolism). It is also involved in the metabolism of N-lactoyl-amino acids, both by hydrolyzing them into lactate and amino acids and by generating these compounds through reverse proteolysis. Additionally, CNDP2 contributes to the regulation of cell cycle arrest and apoptosis.
Technical Parameters
-
Species Human
-
Source E. coli
-
Tag N-6*His
-
Accession
Q96KP4-1 (A2-D475)
-
Gene ID55748
-
Molecular Construction
-
N-term
-
6*His
-
CNDP2 (2-D475)
Accession # Q96KP4-1 -
C-term
-
-
Protein Length
Full Length of Isoform-1
-
Synonyms
Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Peptidase A; CN2; CPGL; HEL-S-13; PEPA
-
AA Sequence
AALTTLFKYIDENQDRYIKKLAKWVAIQSVSAWPEKRGEIRRMMEVAAADVKQLGGSVELVDIGKQKLPDGSEIPLPPILLGRLGSDPQKKTVCIYGHLDVQPAALEDGWDSEPFTLVERDGKLYGRGSTDDKGPVAGWINALEAYQKTGQEIPVNVRFCLEGMEESGSEGLDELIFARKDTFFKDVDYVCISDNYWLGKKKPCITYGLRGICYFFIEVECSNKDLHSGVYGGSVHEAMTDLILLMGSLVDKRGNILIPGINEAVAAVTEEEHKLYDDIDFDIEEFAKDVGAQILLHSHKKDILMHRWRYPSLSLHGIEGAFSGSGAKTVIPRKVVGKFSIRLVPNMTPEVVGEQVTSYLTKKFAELRSPNEFKVYMGHGGKPWVSDFSHPHYLAGRRAMKTVFGVEPDLTREGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEKLNRYNYIEGTKMLAAYLYEVSQLKD
-
Predicted Molecular Mass
56.7kDa
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O . For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
