Copy Link Print Information

EHMT1 Protein, Human

EHMT1 Protein, Human is the recombinant human-derived EHMT1, expressed by E. coli , with tag Free labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: E. coli
  • EHMT1 Protein, Human Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Product Properties
  • Documentation
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Biological Activity

Description

EHMT1 Protein, Human is the recombinant human-derived EHMT1, expressed by E. coli , with tag Free labeled tag.

Background

EHMT1 is a histone methyltransferase that specifically mono- and dimethylates lysine 9 of histone H3 (H3K9me1 and H3K9me2) in euchromatin. H3K9me serves as an epigenetic mark for transcriptional repression by recruiting HP1 proteins to methylated histones. It also weakly methylates lysine 27 of histone H3 (H3K27me) and is involved in DNA methylation (with its histone methyltransferase activity functioning independently of DNA methylation). Likely targeted to histone H3 by DNA-binding proteins such as E2F6, MGA, MAX, or DP1, it contributes to silencing MYC- and E2F-responsive genes during G0 phase, implicating a role in G0/G1 transition regulation. Beyond histone methylation, EHMT1 dimethylates non-histone proteins (e.g., lysine 373 of p53/TP53) and represses mitochondrial function-related genes, potentially through promoter occupancy in concert with BAZ2B (by similarity).

Technical Parameters

  • Species Human
  • Source E. coli
  • Tag Tag Free
  • Accession

    Q9H9B1-1 (N765-A999)

  • Gene ID
    79813
  • Protein Length

    Partial

  • Synonyms

    EUHMTASE1; GLP; KIAA1876; KMT1D

  • AA Sequence

    NFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSA

  • Predicted Molecular Mass

    25.9 kDa

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) Volume (to add to vial)
=
Mass (in vial) Mass (in vial)
÷
Desired Reconstitution Concentration Desired Reconstitution Concentration
Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

Concentration (start) Concentration (start)
×
Volume (start) Volume (start)
=
Concentration (final) Concentration (final)
×
Volume (final) Volume (final)
The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • EHMT1 Protein, Human Product Image
    1/16
  • EHMT1 Protein, Human Product Image