IMPDH2 Protein, Human (His)
Based on 1 Customer Validation
IMPDH2 Protein, Human (His) is the recombinant human-derived IMPDH2, expressed by E. coli , with C-6*His labeled tag. ,
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
IMPDH2 Protein, Human (His) is the recombinant human-derived IMPDH2, expressed by E. coli , with C-6*His labeled tag. ,
IMPDH2 catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, thus playing a crucial role in regulating cell growth. It may also possess single-stranded nucleic acid-binding activity and could be involved in RNA and/or DNA metabolism. Additionally, IMPDH2 might contribute to malignancy development and tumor growth progression. by similar: potentially participates in RNA/DNA metabolism and tumor progression.
Measured by its ability to convert the substrate inosine-5'-phosphate (IMP) to xanthosine-5'-phosphate (XMP). The specific activity is 175.17 pmol/min/μg.
Technical Parameters
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Species Human
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Source E. coli
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Tag C-6*His
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Accession
P12268 (L5-F514)
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Gene ID3615
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Protein Length
Partial
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Synonyms
IMPDH2; IMPD2; Inosine Monophosphate Dehydrogenase 2; IMP (Inosine Monophosphate) Dehydrogenase 2; IMP (Inosine 5'-Monophosphate) Dehydrogenase 2; Epididymis Secretory Sperm Binding Protein; Inosine-5'-Monophosphate Dehydrogenase Type II; Inosine-5'-Monop
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AA Sequence
LISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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Predicted Molecular Mass
62.2 kDa
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Molecular Weight
Approximately 62 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (238 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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