RNF181 Protein, Human
RNF181 Protein, an E3 ubiquitin-protein ligase, mediates the monoubiquitination of the 26S proteasome subunit PSMC2/RPT1. This suggests a role in regulating the 26S proteasome, a vital cellular machinery for protein degradation. RNF181's capacity to modulate PSMC2/RPT1 implies involvement in the intricate regulatory network governing cellular protein homeostasis. RNF181 Protein, Human is the recombinant human-derived RNF181 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
RNF181 Protein, an E3 ubiquitin-protein ligase, mediates the monoubiquitination of the 26S proteasome subunit PSMC2/RPT1. This suggests a role in regulating the 26S proteasome, a vital cellular machinery for protein degradation. RNF181's capacity to modulate PSMC2/RPT1 implies involvement in the intricate regulatory network governing cellular protein homeostasis. RNF181 Protein, Human is the recombinant human-derived RNF181 protein, expressed by E. coli , with tag free.
RNF181 Protein, functioning as an E3 ubiquitin-protein ligase, operates by accepting ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and subsequently directly transferring ubiquitin to its targeted substrates. Notably, RNF181 catalyzes the monoubiquitination of the 26S proteasome subunit PSMC2/RPT1. This activity suggests a role in the regulation of the 26S proteasome, a crucial cellular machinery responsible for protein degradation. The ability of RNF181 to mediate monoubiquitination of PSMC2/RPT1 implies potential involvement in the modulation of proteasomal function, contributing to the intricate regulatory network governing cellular protein homeostasis.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q9P0P0 (A2-T153)
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Gene ID51255
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Molecular Construction
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N-term
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RNF181 (A2-T153)
Accession # Q9P0P0 -
C-term
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Protein Length
Partial
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Synonyms
RNF181; E3 ubiquitin-protein ligase RNF181; RING finger protein 181
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AA Sequence
ASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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