UBCH7 Protein, Mouse
UBCH7 Protein, Mouse is the recombinant mouse-derived UBCH7, expressed by E. coli , with tag Free labeled tag. ,
- Species: Mouse
- Source: E. coli
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
UBCH7 Protein, Mouse is the recombinant mouse-derived UBCH7, expressed by E. coli , with tag Free labeled tag. ,
UBCH7 is a ubiquitin-conjugating enzyme E2 that specifically functions with HECT-type and RBR family E3 ubiquitin-protein ligases. Unlike most RING-containing E3 ligases, it lacks intrinsic E3-independent reactivity with lysine but exhibits activity with RBR family E3 enzymes (e.g., PRKN, RNF31, ARIH1), which operate like RING-HECT hybrids. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to target proteins. By similarity, it mediates ubiquitination by the CUL9-RBX1 complex. In vitro, it catalyzes 'Lys-11'-linked polyubiquitination and participates in the selective degradation of short-lived or abnormal proteins. Downregulated during the S-phase, it contributes to cell cycle progression. Additionally, it regulates nuclear hormone receptor transcriptional activity and may play a role in myelopoiesis.
Technical Parameters
-
Species Mouse
-
Source E. coli
-
Tag Tag Free
-
Accession
P68037 (M1-D154)
-
Gene ID22195
-
Protein Length
Full Length
-
Synonyms
Ubce7
-
AA Sequence
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD
-
Predicted Molecular Mass
17.9 kDa
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
