UHRF2 Protein, Human
UHRF2 protein is an E3 ubiquitin ligase involved in DNA methylation, histone modification, cell cycle regulation and DNA repair. UHRF2 Protein, Human is the recombinant human-derived UHRF2 protein, expressed by E. coli.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
- Documentation
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Biological Activity
UHRF2 protein is an E3 ubiquitin ligase involved in DNA methylation, histone modification, cell cycle regulation and DNA repair. UHRF2 Protein, Human is the recombinant human-derived UHRF2 protein, expressed by E. coli.
UHRF2, an E3 ubiquitin ligase, plays pivotal roles in orchestrating DNA methylation, histone modifications, cell cycle progression, and DNA repair processes. As a specific reader for 5-hydroxymethylcytosine (5hmC), UHRF2 recruits various substrates to these genomic sites, facilitating their ubiquitination and ensuring the maintenance of 5mC levels at specific loci, thereby regulating neuron-related gene expression. In the realm of cell cycle regulation, UHRF2 exerts control by ubiquitinating cyclins CCND1 and CCNE1, leading to G1 arrest. It also targets PCNP for ubiquitin-mediated degradation by the proteasome. Functioning as a key player in DNA damage response, UHRF2 ubiquitinates p21/CDKN1A, promoting its proteasomal degradation and actively participating in DNA repair. Acting as an interstrand cross-links (ICLs) sensor, UHRF2 collaborates with UHRF1 to recruit FANCD2 to ICLs, resulting in FANCD2 monoubiquitination and subsequent activation. Furthermore, UHRF2 contributes to the UV-induced DNA damage response by physically interacting with ATR upon irradiation, thereby facilitating ATR activation.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q96PU4 (W2-R802)
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Gene ID115426
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Molecular Construction
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N-term
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UHRF2 (W2-R802)
Accession # Q96PU4 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
UHRF2; Np95/ICBP90‑Like RING Finger Protein; Ubiquitin Like With PHD And Ring Finger Domains 2; E3 Ubiquitin‑Protein Ligase UHRF2; RNF107; Np95‑Like Ring Finger Protein; NIRF; RING Finger Protein 107; TDRD23; Nuclear Protein 97; URF2; MGC33463; Ubiquitin‑
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AA Sequence
WIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPNFLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHDLGQNYIMIPNEILQTLLDLFFPGYSKGR
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Predicted Molecular Mass
90 kDa
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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