2. Apoptosis
  3. Apoptosis
  4. RM-581

RM-581, aminosteroid, is an orally active anticancer agent. RM-581 shows anticancer potency against pancreatic, breast, prostate, and ovarian cancers. RM-581 induces endoplasmic reticulum stress and apoptosis via disturbance of cancer cell cholesterol homeostasis. RM-581 can be used for the research of cancer, such as prostate cancer and breast cancer.

For research use only. We do not sell to patients.

RM-581

RM-581 Chemical Structure

CAS No. : 2086809-59-6

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RM-581 Related Antibodies

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Description

RM-581, aminosteroid, is an orally active anticancer agent. RM-581 shows anticancer potency against pancreatic, breast, prostate, and ovarian cancers. RM-581 induces endoplasmic reticulum stress and apoptosis via disturbance of cancer cell cholesterol homeostasis. RM-581 can be used for the research of cancer, such as prostate cancer and breast cancer[1].

Cellular Effect
Cell Line Type Value Description References
LAPC4 IC50
0.6 μM
Compound: RM-581
Antiproliferative activity against human LAPC4 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human LAPC4 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
LNCaP IC50
1.2 μM
Compound: RM-581
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
MCF7 IC50
2.6 μM
Compound: RM-581
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
OVCAR-3 IC50
5 μM
Compound: RM-581
Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
PANC-1 IC50
3.9 μM
Compound: RM-581
Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human PANC-1 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
PC-3 IC50
1.6 μM
Compound: RM-581
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
T47D IC50
0.5 μM
Compound: RM-581
Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTS assay
Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 72 hrs by MTS assay
[PMID: 31893547]
In Vitro

RM-581 (1-5 μM; 3 days) inhibits proliferation of prostate (PC-3, LAPC-4, LNCaP), breast (MCF-7, T-47D), pancreatic (PANC-1), and ovarian (OVCAR-3) cancer cell lines with mean IC50 values ranging from 1.1 μM to 5.0 μM[1].
RM-581 (10 μM; 1 h) shows moderate metabolic stability in human liver S9 fraction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RM-581 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: LAPC-4, PC-3, LNCaP, MCF-7, T-47D, PANC-1, OVCAR-3
Concentration: 1 μM, 5 μM
Incubation Time: 3 days
Result: Inhibited cell proliferation with IC50 values: 1.6 μM (PC-3), 0.6 μM (LAPC-4), 1.2 μM (LNCaP), 2.6 μM (MCF-7), 0.5 μM (T-47D), 3.9 μM (PANC-1), 5.0 μM (OVCAR-3).
Exhibited mean IC50 values of 1.1 μM (prostate cancer cells), 1.5 μM (breast cancer cells), 3.9 μM (pancreatic cancer cells), and 5.0 μM (ovarian cancer cells).
In Vivo

RM-581 (60 mg/kg, s.c., 6 days/week for 28 days) exhibits in vivo anticancer efficacy with tumor regression in nude mouse MCF-7 breast cancer xenografts[2].
RM-581 (10-80 mg/kg, i.g., daily for 5 weeks) inhibits tumor growth in a PANC-1-Luc cell-derived orthotopic xenograft model in nu/nu mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 17β-estradiol (E2)-induced growth of human MCF-7 breast
tumors in ovariectomized (OVX) nude mice[2]
Dosage: 60 mg/kg
Administration: s.c., 6 days/week for 28 days
Result: Reduced tumor size and weight.
Animal Model: PANC-1-Luc cell-derived orthotopic xenograft model in nu/nu mice[3]
Dosage: 10, 40, 80 mg/kg
Administration: i.g., daily for 5 weeks
Result: Showed inhibited tumor growth of 11, 54 and 76% at 10, 40 and 80 mg/kg, respectively.
Molecular Weight

646.82

Formula

C40H46N4O4
CAS No.
SMILES

C[C@@]12[C@](CC[C@@]2(O)C#C)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(N5CCN(CC5)C([C@H]6N(CCC6)C(C7=NC8=C(C=CC=C8)C=C7)=O)=O)=C(OC)C=C4CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RM-581 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RM-5812086809-59-6RM581RM 581Apoptosisapoptosischolesterol homeostasisLAPC-4LNCaPendoplasmic reticulum stressovarian cancerpancreatic cancerPC-3prostate cancerbreast cancerInhibitorinhibitorinhibit

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