FGF10 - fibroblast growth factor 10 Gene
Species: Homo sapiens
About FGF10
This gene has 2 transcripts (splice variants), 275 orthologues, 21 paralogues and is associated with 6 phenotypes. Broad expression in ovary (RPKM 9.2), fat (RPKM 4.7) and 15 other tissues.
Summary
The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
FGF10 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_004465.2 | NP_004456.1 | fibroblast growth factor 10 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables chemoattractant activity |
IDA
IDA: Inferred from direct assay
|
9740653 | GOA |
| enables fibroblast growth factor receptor binding |
IDA
IDA: Inferred from direct assay
|
11923311 | GOA |
| enables growth factor activity |
IDA
IDA: Inferred from direct assay
|
11923311 | GOA |
| enables heparin binding |
IDA
IDA: Inferred from direct assay
|
11923311 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12591959 | GOA |
| enables type 2 fibroblast growth factor receptor binding |
IPI
IPI: Inferred from physical interaction
|
19224135 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
16597614 | GOA |
| colocalizes with collagen-containing extracellular matrix |
IDA
IDA: Inferred from direct assay
|
17959718 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
16597614 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
11923311 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
16597614 | GOA |
FGF10 Protein Structure
FGF: Fibroblast growth factor (78 - 202)
- 0
- 100
- 208 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
fibroblast growth factor 10 |
|
FGF10 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
FGF10 | O15520 | SREK1IP1 | Homo sapiens | Q8N9Q2 | 32296183 | |
|
Intra
|
FGF10 | O15520 | FGFR2 | Homo sapiens | P21802 | 25241761 | |
|
Intra
|
FGF10 | O15520 | FGFR2 | Homo sapiens | P21802 | 12591959 | |
|
Intra
|
FGF10 | O15520 | THAP1 | Homo sapiens | Q9NVV9 | 32296183 | |
|
Intra
|
FGF10 | O15520 | THAP1 | Homo sapiens | Q9NVV9 | 32296183 | |
|
Intra
|
FGF10 | O15520 | THAP1 | Homo sapiens | Q9NVV9 | 32296183 |
Recombinant FGF10 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7048 | KGF-2/FGF-10 Protein, Human (169a.a) | O15520 (L40-S208) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P78123 | KGF-2/FGF-10 Protein, Human (Biotinylated) | O15520 (Q38-S208) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78878 | KGF-2/FGF-10 Protein, Human (Biotinylated, His-Avi) | O15520 (Q38-S208) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7342AF | Animal-Free KGF-2/FGF-10 Protein, Human (His) | O15520 (L40-S208) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700279 | KGF-2/FGF-10 Protein, Human (N-His) | O15520 (L40-S208) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Lacrimoauriculodentodigital Syndrome |
|
|
| Aplasia Of Lacrimal And Salivary Glands |
|
|
| Pulmonary Hypoplasia, Primary |
|
|
| Pulmonary Hypoplasia, Familial Primary |
|
|
| Apert Syndrome |
|
|
| Craniosynostosis |
|
|
| Acanthoma |
|
|
| Pfeiffer Syndrome |
|
|
| Blastoma |
|
|
| Hypospadias |
|
|
| Bronchopulmonary Dysplasia |
|
|
| Cleft Lip |
|
|
| Tracheomalacia |
|
|
| Duodenal Atresia |
|
|
| Ischiocoxopodopatellar Syndrome With Or Without Pulmonary Arterial Hypertension |
|
|
| Exudative Vitreoretinopathy 7 |
|
|
| Cataract 23, Multiple Types |
|
|
| Chronic Inflammation Of Lacrimal Passage |
|
|
| Dacryocystocele |
|
|
| Muenke Syndrome |
|
|
| Mucositis |
|
|
| Mesenteric Vascular Occlusion |
|
|
| Tracheal Stenosis |
|
|
| Cleft Palate, Isolated |
|
|
| Intestinal Atresia |
|
|
| Ectodermal Dysplasia |
|
|
| Diaphragm Disease |
|
|
| Crouzon Syndrome |
|
|
| Neonatal Respiratory Failure |
|
|
| Tracheal Disease |
|
|
| Granulomatous Endometritis |
|
|
| Ectopic Thymus |
|
|
| Holt-Oram Syndrome |
|
|
| Jackson-Weiss Syndrome |
|
|
| Renal Hypodysplasia/Aplasia 1 |
|
|
| Orofacial Cleft |
|
|
| Diaphragmatic Hernia, Congenital |
|
|
| Developmental And Epileptic Encephalopathy 24 |
|
|
| Myopia |
|
|
| Breast Cancer |
|
|
| Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive |
|
|
| Double Outlet Right Ventricle |
|
|
| Branchiooculofacial Syndrome |
|
|
| Tooth Agenesis |
|
|
| Esophageal Atresia |
|
|
| Tetralogy Of Fallot |
|
|
| Interstitial Lung Disease 2 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | FGF10 | RGD | RGD:2606 |
| Macaca mulatta | FGF10 | VGNC | VGNC:84378 |
| Mus musculus | FGF10 | MGD | MGI:1099809 |
| Felis catus | FGF10 | VGNC | VGNC:102207 |
| Canis familiaris | FGF10 | VGNC | VGNC:40839 |
| Bos taurus | FGF10 | VGNC | VGNC:106742 |
| Others | FGF10 | NCBI |