NQO2 - N-ribosyldihydronicotinamide:quinone reductase 2 Gene

Also Known as QR2; DHQV; DIA6; NMOR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4835

About NQO2

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:2,999,894-3,019,755 (from NCBI)

This gene has 9 transcripts (splice variants), 258 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in kidney (RPKM 43.3), fat (RPKM 18.6) and 24 other tissues.

Summary

This gene encodes a member of the thioredoxin family of Enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

NQO2 Products (4)

mRNA	Protein	Name
NM_000904.6	NP_000895.2	ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
NM_001290221.2	NP_001277150.1	ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
NM_001290222.2	NP_001277151.1	ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2
NM_001318940.2	NP_001305869.1	ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables FAD binding	IDA IDA: Inferred from direct assay	18254726	GOA
enables chloride ion binding	IDA IDA: Inferred from direct assay	18254726	GOA
enables dihydronicotinamide riboside quinone reductase activity	IDA IDA: Inferred from direct assay	18254726	GOA
enables electron transfer activity	IDA IDA: Inferred from direct assay	10945627	GOA
enables melatonin binding	IDA IDA: Inferred from direct assay	18254726	GOA
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	10945627	GOA
enables oxidoreductase activity, acting on other nitrogenous compounds as donors	IDA IDA: Inferred from direct assay	10945627	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	18254726	GOA
enables resveratrol binding	IDA IDA: Inferred from direct assay	18254726	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18254726	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in quinone catabolic process	IDA IDA: Inferred from direct assay	18254726	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	10945627	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NQO2 Protein Structure

Flavodoxin_2

0
100
200
231 a.a.

Protein Preferred Names	Protein Names
ribosyldihydronicotinamide dehydrogenase [quinone]	NAD(P)H dehydrogenase, quinone 2

NQO2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NQO2	P16083	LRRC7	Homo sapiens	A1L1C6	Y2H Prey Pooling	25416956
Intra	NQO2	P16083	LRRC7	Homo sapiens	A1L1C6	Y2H Array	25416956
Intra	NQO2	P16083	GORASP2	Homo sapiens	Q9H8Y8	Y2H Pooling	16189514
Intra	NQO2	P16083	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	NQO2	P16083	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	31515488
Intra	NQO2	P16083	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	NQO2	P16083	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	NQO2	P16083	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	NQO2	P16083	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183
Intra	NQO2	P16083	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	NQO2	P16083	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
Intra	NQO2	P16083	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

NQO2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82542	NQO2 Antibody (YA2287)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Familial Adenomatous Polyposis 3	FAP3 Nthl1-Related Attenuated Familial Adenomatous Polyposis Nthl1-Related Afap Nthl1-Related Attenuated Fap
Granulocytopenia	Agranulocytosis
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117393	Bisindolylmaleimide III	Inhibitor	98.95%	Unkown
HY-180168	NQO2 activator-1	Activator	/	Unkown
HY-W843391	Caricotamide	Activator	/	Unkown
HY-112454	Bisindolylmaleimide III hydrochloride	Inhibitor	/	Unkown
HY-N9765	threo-Guaiacylglycerol β-coniferyl ether	Control	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NQO2	VGNC	VGNC:75500
Bos taurus	NQO2	VGNC	VGNC:32225
Felis catus	NQO2	VGNC	VGNC:68506
Canis familiaris	NQO2	VGNC	VGNC:59138
Mus musculus	NQO2	MGD	MGI:104513
Rattus norvegicus	NQO2	RGD	RGD:1303320
Others	NQO2	NCBI