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106928-29-4

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1 Results for "106928-29-4" in MCE Product Catalog:

Hapalindole Q
Hapalindole Q
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Cat. No.: HY-173150
CAS No.: 106928-29-4
Category:  

Alkaloids Microorganisms Other Alkaloids

Target:  

YAP

Hapalindole Q (Compound (+)-1) is an autophagy (Autophagy) inhibitor targeting YAP1. Hapalindole Q binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM and induces its degradation via the chaperone-mediated autophagy (CMA) pathway. This process inhibits Rab7-mediated fusion of autophagosomes and lysosomes, thereby reducing overall autophagy levels without affecting lysosomal function. Hapalindole Q holds promise for research in cancer (e.g., liver cancer, breast cancer, etc.) .
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