106928-29-4
Chemical Structure
Hapalindole Q
- CAS No.: 106928-29-4
- Formula:C21H24N2S
- Molecular Weight:336.49
InChIKey: PPHWDUZMWNUINO-NOOVBMIQSA-N
SMILES: C[C@](CC[C@H]([C@@H]1C2=CNC3=CC=CC=C32)C(C)=C)([C@@H]1N=C=S)C=C
Biological Activity: Hapalindole Q (Compound (+)-1) is an autophagy (Autophagy) inhibitor targeting YAP1. Hapalindole Q binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM and induces its degradation via the chaperone-mediated autophagy (CMA) pathway. This process inhibits Rab7-mediated fusion of autophagosomes and lysosomes, thereby reducing overall autophagy levels without affecting lysosomal function. Hapalindole Q holds promise for research in cancer (e.g., liver cancer, breast cancer, etc.)[1].
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Hapalindole Q | Hapalindole Q (Compound (+)-1) is an autophagy (Autophagy) inhibitor targeting YAP1. Hapalindole Q binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM and induces its degradation via the chaperone-mediated autophagy (CMA) pathway. This process inhibits Rab7-mediated fusion of autophagosomes and lysosomes, thereby reducing overall autophagy levels without affecting lysosomal function. Hapalindole Q holds promise for research in cancer (e.g., liver cancer, breast cancer, etc.). | |||||||||||||||||||||
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Keywords
