2 Results for "

486-39-5

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "486-39-5" in MCE Product Catalog:

1
Coclaurine
Coclaurine
0 Images
1 Cited Publications
Cat. No.: HY-N3610
CAS No.: 486-39-5
Category:  

Alkaloids Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.

Target:  

nAChR

Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin (HY-17394) sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription .
loading...
    loading...
View All Sizes
1
(-)-Coclaurine hydrochloride
(-)-Coclaurine hydrochloride
0 Images
1 Cited Publications
Cat. No.: HY-W705106
CAS No.: 3422-42-2
Synonyms: (-)-(S)-Coclaurine hydrochloride; L-Coclaurine hydrochloride
Category:  

Alkaloids Piperidine Alkaloids Cocculus laurifolius DC. Plants Menispermaceae

Target:  

nAChR

(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist .
loading...
    loading...
View All Sizes
Assay Types