1 Result for "

7-Ketositosterol

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "7-Ketositosterol" in MCE Product Catalog:

7-Ketositosterol
7-Ketositosterol
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Cat. No.: HY-N2757
CAS No.: 2034-74-4
Category:  

Plants Moraceae Morus alba Linn. Steroids

Target:  

Apoptosis Ferroptosis ERK NF-κB p38 MAPK Reactive Oxygen Species (ROS)

7-Ketositosterol is an orally active inducer of apoptosis and ferroptosis. 7-Ketositosterol inhibits the phosphorylation of ERK1/2 and NF-κB, promotes the opening of the mitochondrial/apoptotic pathway, and induces ferroptosis in macrophages by increasing the levels of malondialdehyde, Fe 2+ and ROS. 7-Ketositosterol upregulates the expression of gut microbiota-dependent PDLIM3, activates the p38MAPK/NF-κB signaling pathway, alters the composition of gut microbiota, increases the abundance of pathogenic bacteria, and exacerbates colitis in mice. 7-Ketositosterol can be used in studies related to breast cancer, liver cancer, and colitis .
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