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ACBI 3

" in MedChemExpress (MCE) Product Catalog:

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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-157228
    ACBI3

    		PROTACs Ras Cancer
    ACBI3 (compound 7), a chemical probe, is a PROTAC targeting KRAS. ACBI3 is composed of PROTAC target protein ligand pan-KRAS degrader 1 (HY-162960) (red part), E3 ligase ligand E3 ligase Ligand 43 (HY-401613) (blue part) and PROTAC Linker 1-Bromo-4-(ethynyloxy)butane (HY-169992) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is E3 Ligase Ligand-linker Conjugate 143 (HY-169995). ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models .
    ACBI3
  • HY-169992
    1-Bromo-4-(ethynyloxy)butane

    		PROTAC Linkers Others
    1-Bromo-4-(ethynyloxy)butane is the PROTAC linker of ACBI3 (HY-157228) and can be used in the synthesis of PROTACs .
    1-Bromo-4-(ethynyloxy)butane
  • HY-169995
    E3 Ligase Ligand-linker Conjugate 143

    		E3 Ligase Ligand-Linker Conjugates Cancer
    E3 Ligase Ligand-linker Conjugate 143 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of ACBI3 (HY-157228) .
    E3 Ligase Ligand-linker Conjugate 143
  • HY-401613
    E3 ligase Ligand 43

    		Ligands for E3 Ligase Cancer
    E3 ligase Ligand 43 serves as the E3 ubiquitin ligase ligand for ACBI3 (HY-157228). E3 ligase Ligand 43 can be utilized for the synthesis of PROTACs .
    E3 ligase Ligand 43

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