2938169-76-5
2938169-76-5
Chemical Structure
ACBI3
- CAS. Nr.: 2938169-76-5
- Formula:C50H62N14O6S2
- Molecular Weight:1019.25
InChIKey: DQRZNYPHOWVXPQ-YDUPODKQSA-N
SMILES: NC(SC1=C2[C@](C3=NC(C4=NC(N5CCCN(CCCCOC(N=N6)=CN6[C@@H](C(C)C)C(N7[C@H](C(N[C@@H](CO)C8=CC=C(C=C8)C9=C(N=CS9)C)=O)C[C@@H](O)C7)=O)C[C@@H]5C)=NC=C4)=NO3)(C)CCC1)=C2C#N
Biological Activity: ACBI3 (compound 7), a chemical probe, is a PROTAC targeting KRAS. ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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ACBI3 | 99.47% | ACBI3 (compound 7), a chemical probe, is a PROTAC targeting KRAS. ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models. | ||||||||||||||||||||
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References
- [1]. Popow J, et al. Targeting cancer with small molecule pan-KRAS degraders[J]. bioRxiv, 2023: 2023.10. 24.563163.
- [2]. Hamilton G, et al. Development of PROTACS degrading KRAS and SOS1. Oncol Res. 2024 Jul 17;32(8):1257-1264. [Content Brief]
- [3]. Cox AD, et al. KRAS takes the road to destruction. Science. 2024 Sep 20;385(6715):1274-1275. [Content Brief]
Keywords
