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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
ADGRD1
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "ADGRD1" in MCE Product Catalog:
Cat. No.: HY-177108
CAS No.: 767299-99-0
Research Areas:
AP-503 is a selective GPR133/ADGRD1 agonist with an EC50 of 1.21 nM. AP-503 is used in research on the prevention of muscle-related diseases and vestibular dysfunction [1].
Cat. No.: HY-175232
CAS No.: 488801-10-1
Research Areas:
GL64 is a selective agonist of ADGRD1 (EC50 = 3.98 μM). GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases [1].
Cat. No.: HY-RS00348
Target:
Research Areas:
ADGRD1 Human Pre-designed siRNA Set A contains three designed siRNAs for ADGRD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21814
Target:
Research Areas:
Adgrd1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adgrd1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS28330
Target:
Research Areas:
Adgrd1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adgrd1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-186252
CAS No.: 3103571-04-3
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
GPR133 agonist 1 is an orally active GPR133/ADGRD1 agonist with an EC50 of 1.6 nM (293T cells). GPR133 agonist 1 activates GPR133, thereby regulating the downstream cAMP signaling pathway. GPR133 agonist 1 enhances muscle strength and endurance in mice. GPR133 agonist 1 can be used in research related to muscular atrophy, myasthenia, sarcopenia, erectile dysfunction, vestibular dysfunction, obesity, and non-alcoholic fatty liver disease [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
