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ALR2-IN-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-150630
    ALR2-IN-1

    		Aldose Reductase Metabolic Disease
    ALR2-IN-1 is a potent and selective ALR2 inhibitor (IC50=1.42 μM). ALR2-IN-1 shows antioxidant and antiglycative properties. ALR2-IN-1 can be used in diabetic complication research .
    ALR2-IN-1
  • HY-175331
    ALR2-IN-7

    		Aldose Reductase Metabolic Disease Cancer
    ALR2-IN-7 (Compound 5a) is a highly potent and selective aldose reductase (ALR2/AKR1B1) inhibitor (Ki=8.71 nM). ALR2-IN-7 is promising for research of diabetic complications (e.g., retinopathy, nephropathy) and cancers .
    ALR2-IN-7
  • HY-175639
    ALR2-IN-8

    		Aldose Reductase Metabolic Disease Inflammation/Immunology
    ALR2-IN-8 is a potent aldose reductase (ALR2/AKR1B1) inhibitor with a KI of 7.34 nM. ALR2-IN-8 has extremely low toxicity to normal cells and has a weak direct killing effect on cancer cells. ALR2-IN-8 can used for the studies of diabetic and inflammation-linked disorders .
    ALR2-IN-8
  • HY-146661
    Aldose reductase-IN-4

    		Aldose Reductase Cancer
    Aldose reductase-IN-4 (compund IIc) is an aldose reductase inhibitor with IC50s of 11.70 μM and 0.98 μM for aldehyde reductase 1 (ALR1) and ALR2, respectively .
    Aldose reductase-IN-4
  • HY-182311
    ALR2/α-Glucosidase-IN-1

    		Aldose Reductase Glycosidase Metabolic Disease
    ALR2/α-Glucosidase-IN-1 (Compound 4) is a competitive ALR2 inhibitor and competitive α-glucosidase inhibitor, with an IC50 of 0.250 μM against ALR2 and an IC50 of 0.561 μM against α-glucosidase. ALR2/α-Glucosidase-IN-1 binds to the active sites of ALR2 and α-glucosidase, and inhibits enzymatic activity by competing with their respective substrates. ALR2/α-Glucosidase-IN-1 can be used in diabetes-related research .
    ALR2/α-Glucosidase-IN-1
  • HY-181519
    ALR2/α-GLY-IN-1

    		DNA Alkylator/Crosslinker Aldose Reductase Glycosidase Metabolic Disease Inflammation/Immunology
    ALR2/α-GLY-IN-1 is a potent dual-target inhibitor that targets aldose reductase ALR2 and α-glucosidase (IC50 values are 0.72 μM and 0.82 μM, respectively; Ki values are 1.67 μM and 1.37 μM, respectively). ALR2/α-GLY-IN-1 also acts as a DNA binder, which stably interacts with calf thymus double-stranded DNA through non-covalent interactions such as groove-binding mode and water-bridged hydrogen bonds. ALR2/α-GLY-IN-1 can be used in studies related to diabetes and its complications .
    ALR2/α-GLY-IN-1

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