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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
AP-2α
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "AP-2α" in MCE Product Catalog:
1
1 Cited Publications
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LEI110 is a pan-inhibitor of the HRASLS family and an inhibitor of AP-2α, with a Ki of 20 nM against PLA2G16. LEI110 exhibits inhibitory activity against PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8 and 7.6, respectively. LEI110 binds to the active site of PLA2G16, reduces intracellular arachidonic acid levels, and attenuates oleic acid-induced lipolysis. LEI110 stabilizes AP-2α, impairs its DNA-binding ability, inhibits the transcription of DNA damage repair genes, induces the accumulation of oxidative DNA damage, suppresses cell proliferation and clonogenicity, and sensitizes HCC cells to DNA-damaging agents. LEI110 can be used in research related to obesity, fatty liver disease, the common cold and hepatocellular carcinoma [2].
Cat. No.: HY-P82364A
Synonyms: AP-2; BOFS; AP2TF; TFAP2; AP-2alpha
Cat. No.: HY-P83704
Synonyms: Activating enhancer binding protein 2 alpha antibody;
Activating enhancer-binding protein 2-alpha antibody;
Activator protein 2 antibody;
AP 2 transcription factor antibody;
AP 2alpha antibody;
AP-2 antibody;
AP-2 transcription factor antibody;
AP2 antibody;
AP2 Transcription Factor antibody;
AP2-alpha antibody;
AP2A_HUMAN antibody;
AP2TF antibody;
BOFS antibody;
FLJ51761 antibody;
TFAP 2 antibody;
TFAP 2A antibody;
TFAP2 antibody;
TFAP2A antibody;
Transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha) antibody;
Transcription factor AP-2-alpha antibody;
Transcription factor AP2 alpha antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
